Reactome | PRPF19 [nucleoplasm]

PRPF19 [nucleoplasm]

Stable Identifier

R-BTA-5420907

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

PRPF19, Q08E38

Locations in the PathwayBrowser

Expand all

DNA Repair (Bos taurus)

- Nucleotide Excision Repair (Bos taurus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
    - Dual incision in TC-NER (Bos taurus)
      - 3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
        
        TC-NER incision complex [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)
        
        TC-NER incision complex [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
        
        TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - ERCC5 and RPA bind TC-NER site (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
    - Formation of TC-NER Pre-Incision Complex (Bos taurus)
      - Assembly of the pre-incision complex in TC-NER (Bos taurus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
        
        TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        PRPF19 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q08E38

Gene Names

PRPF19

Reference Genes

BioGPS Gene:513868 PRPF19

ENSEMBL:ENSBTAG00000014366

ENSEMBL:ENSBTAG00000014366.6 PRPF19

Monarch:513868 PRPF19

NCBI Gene:513868 PRPF19

Reference Transcript

RefSeq:NM_001075640.1 PRPF19

Other Identifiers

513868

GO:0000398

GO:0000974

GO:0003824

GO:0004842

GO:0005515

GO:0006281

GO:0016071

GO:0016567

GO:0016740

GO:0036211

GO:0061630

GO:0140096

Participates

as a component of

Inferred From

PRPF19 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001069108.1

OpenTargets

ENSG00000110107

IntEnz

2.3.2.27

Ensembl

ENSBTAG00000014366, ENSBTAP00000019100, ENSBTAT00000019100

VGNC

33372

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