Translocation of 55S ribosome by 3 bases in the 3' direction

Stable Identifier
R-BTA-5432422
Type
Reaction [transition]
Species
Bos taurus
Compartment
mitochondrial matrix, mitochondrial inner membrane
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
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 | PPTX  | SBGN
Translocation of 55S ribosome by 3 bases in the 3' direction
As inferred from human entities, bovine GFM1 of the GFM1:GTP complex hydrolyzes GTP, yielding GFM1:GDP. The hydrolysis of GTP drives translocation of the ribosome in the 3' direction on the mRNA. The translocation ejects the deacylated tRNA from the P site of the ribosome and shifts the peptidyl-tRNA from the A site to the P site.
Literature References
PubMed ID Title Journal Year
2250005 Purification and characterization of elongation factor G from bovine liver mitochondria

Spremulli, LL, Chung, HK

J. Biol. Chem. 1990
Participants
Input
Output
Catalyst Activity

GTPase activity of 55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane]

Physical Entity
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Bos taurus)
Activity
GTPase activity (GO:0003924)
Orthologous Events
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
Authored
May, B  (2014-05-09)
Reviewed
Chrzanowska-Lightowlers, ZM  (2014-08-29)
Created
May, B  (2014-05-11)
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