TUFM binds GTP displacing TSFM

Stable Identifier
R-BTA-5432551
Type
Reaction [transition]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
TUFM binds GTP displacing TSFM

TSFM (EF-Ts, EF-TsMt) acts as a guanine nucleotide exchange factor for TUFM (EF-Tu) to regenerate TUFM:GTP from TUFM:GDP. In the second step of the process TUFM in the TUFM:TSFM complex binds GTP and TSFM is released, yielding TUFM:GTP and TSFM (Kumazawa et al. 1991, Schwartzbach and Spremulli 1991, Cai et al. 2000).

Literature References
PubMed ID Title Journal Year
1885567 Interaction of animal mitochondrial EF-Tu.EF-Ts with aminoacyl-tRNA, guanine nucleotides, and ribosomes

Schwartzbach, CJ, Spremulli, LL

J. Biol. Chem. 1991
1932108 Interactions of bovine mitochondrial phenylalanyl-tRNA with ribosomes and elongation factors from mitochondria and bacteria

Kumazawa, Y, Schwartzbach, CJ, Liao, HX, Mizumoto, K, Kaziro, Y, Miura, K, Watanabe, K, Spremulli, LL

Biochim. Biophys. Acta 1991
11045624 Interaction of mammalian mitochondrial elongation factor EF-Tu with guanine nucleotides

Cai, YC, Bullard, JM, Thompson, NL, Spremulli, LL

Protein Sci. 2000
10801827 Interaction of mitochondrial elongation factor Tu with aminoacyl-tRNA and elongation factor Ts

Cai, YC, Bullard, JM, Thompson, NL, Spremulli, LL

J. Biol. Chem. 2000
Participants
Orthologous Events
Authored
Reviewed
Created