Reactome | MARK3 [cytosol]

MARK3 [cytosol]

Stable Identifier

R-BTA-5672591

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

A0A3Q1M888

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - MAP2K and MAPK activation (Bos taurus)
        
        Dissociation of RAS:RAF complex (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        MAP2Ks phosphorylate MAPKs (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        RAF phosphorylates MAP2K dimer (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Bos taurus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Bos taurus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
        
        RAF/MAPK scaffolds [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
      - Negative regulation of MAPK pathway (Bos taurus)
        
        BRAP binds KSR1:MARK3 (Bos taurus)
        
        BRAP:KSR1:MARK3 [cytosol] (Bos taurus)
        
        KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
      - RAF activation (Bos taurus)
        
        MARK3 phosphorylates KSR1 (Bos taurus)
        
        KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        PP2A dephosphorylates KSR1 (Bos taurus)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Bos taurus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        Phosphorylation of RAF (Bos taurus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Bos taurus)
        
        activated RAF/KSR1 [plasma membrane] (Bos taurus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Bos taurus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)
        
        BRAP:KSR1:MARK3 [cytosol] (Bos taurus)
        
        KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Bos taurus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        Raf dimer inhibitors bind RAF heterodimers (Bos taurus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Bos taurus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Bos taurus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Bos taurus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        YWHAB dimer dissociates from KSR1:MARK3 (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Bos taurus)
        
        p-S311 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Bos taurus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Bos taurus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Bos taurus)
        
        MARK3 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1M888

Reference Genes

ENSEMBL:ENSBTAG00000013410.6

Reference Transcript

RefSeq:XM_010817354.2

Other Identifiers

534872

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005737

GO:0005886

GO:0006468

GO:0016740

GO:0023052

GO:0030425

GO:0035556

GO:0036211

GO:0042995

GO:0106310

GO:0140096

Participates

as a component of

Inferred From

MARK3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_010815656.1

Ensembl

ENSBTAT00000079194, ENSBTAP00000066650, ENSBTAG00000013410

VGNC

31249

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