Reactome | XRCC3 [nucleoplasm]

XRCC3 [nucleoplasm]

Stable Identifier

R-BTA-5685303

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

XRCC3, A0A452DJ33

Locations in the PathwayBrowser

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DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - Homology Directed Repair (Bos taurus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
      - HDR through Homologous Recombination (HRR) (Bos taurus)
        
        D-loop extension by DNA polymerases (Bos taurus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Homologous DNA Pairing and Strand Exchange (Bos taurus)
        
        CX3 complex binds D-loop structures (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        CX3 complex formation (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Resolution of D-Loop Structures (Bos taurus)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Bos taurus)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Bos taurus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Bos taurus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        MUS81:EME1,EME2 cleaves D-loop (Bos taurus)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Bos taurus)
        
        CX3 complex [nucleoplasm] (Bos taurus)
        
        XRCC3 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A452DJ33

Gene Names

XRCC3

Reference Genes

BioGPS Gene:768244 XRCC3

ENSEMBL:ENSBTAG00000009966.5

Monarch:768244 XRCC3

NCBI Gene:768244 XRCC3

Reference Transcript

RefSeq:XM_005222253.3 XRCC3

Other Identifiers

768244

GO:0000400

GO:0000722

GO:0003677

GO:0003824

GO:0005524

GO:0005634

GO:0005657

GO:0005694

GO:0006281

GO:0006310

GO:0032200

GO:0033065

GO:0043226

GO:0045003

GO:0071140

GO:0090656

GO:0140097

GO:0140299

GO:0140657

GO:0140664

Participates

as an input of

CX3 complex formation (Bos taurus)

as a component of

CX3 complex [nucleoplasm] (Bos taurus)

Inferred From

XRCC3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005222310.1

OpenTargets

ENSG00000126215

Ensembl

ENSBTAP00000013145, ENSBTAT00000013145, ENSBTAG00000009966

VGNC

37004

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