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phospho-Ub,p-S2,S5-POLR2A [nucleoplasm]
Stable Identifier
R-BTA-6781855
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
G3MZY8
Locations in the PathwayBrowser
Expand all
DNA Repair (Bos taurus)
Nucleotide Excision Repair (Bos taurus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Dual incision in TC-NER (Bos taurus)
3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
TC-NER incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)
TC-NER incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
ERCC5 and RPA bind TC-NER site (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
RNA Pol II backtracking in TC-NER (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
Formation of TC-NER Pre-Incision Complex (Bos taurus)
Assembly of the pre-incision complex in TC-NER (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Bos taurus)
phospho-Ub,p-S2,S5-POLR2A [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:G3MZY8
Reference Genes
BioGPS Gene:282312
ENSEMBL:ENSBTAG00000046765
KEGG Gene (Bos taurus):282312
Monarch:282312
NCBI Gene:282312
Reference Transcript
RefSeq:NM_001206313.1
Other Identifiers
282312
5FLM
5OIK
Bt.17009.1.A1_at
Bt.3385.2.S1_at
ENSBTAG00000046765
ENSBTAP00000055142
ENSBTAP00000065848
ENSBTAT00000064788
ENSBTAT00000069267
EntrezGene:282312
EntrezGene:POLR2A
GO:0001055
GO:0003674
GO:0003677
GO:0003899
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005665
GO:0006351
GO:0006366
GO:0008150
GO:0009058
GO:0016740
GO:0016779
GO:0032991
GO:0034641
GO:0043226
IPR000684
IPR000722
IPR006592
IPR007066
IPR007073
IPR007075
IPR007080
IPR007081
IPR007083
IPR038120
IPR038593
IPR042102
NM_001206313
NP_001193242
PF00623
PF04983
PF04990
PF04992
PF04997
PF04998
PF05000
PF05001
POLR2A
POLR2A-201
POLR2A-202
PR01217
SM00663
UPI0000EBDCD2
VGNC:33135
XM_024979629
XM_024979630
XP_024835397
XP_024835398
Participant Of
hasComponent
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm]
Other forms of this molecule
phospho-p-S2,S7-POLR2A [nucleoplasm]
phospho-p-S5,S7-POLR2A [nucleoplasm]
phospho-p-S5-POLR2A [nucleoplasm]
POLR2A [nucleoplasm]
phospho-p-3S-POLR2A [nucleoplasm]
phospho-p-S2,S5-POLR2A [nucleoplasm]
Inferred From
Ub,p-S2,S5-POLR2A [nucleoplasm] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 5 (in Homo sapiens)
Coordinate
5
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001193242.1
PDB
5FLM
,
5OIK
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