Reactome | ANAPC16 [cytosol]

ANAPC16 [cytosol]

Stable Identifier

R-BTA-6805138

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

ANAPC16, Q58DR0

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - Mitotic Spindle Checkpoint (Bos taurus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
        
        Binding of the MCC complex to the APC/C complex (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Metaphase and Anaphase (Bos taurus)
      - Mitotic Anaphase (Bos taurus)
        
        Separation of Sister Chromatids (Bos taurus)
        
        Association of Securin with Cdc20:APC/C complex (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Degradation of multiubiquitinated Securin (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
  - Regulation of mitotic cell cycle (Bos taurus)
    - APC/C-mediated degradation of cell cycle proteins (Bos taurus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Bos taurus)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Degradation of multiubiquitinated Cyclin B (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        APC/C:Cdc20 mediated degradation of Securin (Bos taurus)
        
        Association of Securin with Cdc20:APC/C complex (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Degradation of multiubiquitinated Securin (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Bos taurus)
        
        APC-Cdc20 mediated degradation of Nek2A (Bos taurus)
        
        Association of Nek2A with MCC:APC/C (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Degradation of multiubiquitinated Nek2A (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Multiubiquitinated Nek2A [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Multiubiquitination of Nek2A (Bos taurus)
        
        Multiubiquitinated Nek2A [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Bos taurus)
        
        Association of Cyclin A with the APC/C (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Degradation multiubiquitinated Cyclin A (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
        
        Association of Cdh1 with the APC/C (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        Dissociation of Cdc20 from APC/C complex (Bos taurus)
        
        CDC20:p-APC/C [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
      - Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
        
        Binding of the MCC complex to the APC/C complex (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)
  - S Phase (Bos taurus)
    - Synthesis of DNA (Bos taurus)
      - Switching of origins to a post-replicative state (Bos taurus)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
        
        ANAPC16 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q58DR0

Gene Names

ANAPC16

Reference Genes

BioGPS Gene:540089 ANAPC16

ENSEMBL:ENSBTAG00000000162

ENSEMBL:ENSBTAG00000000162.5 ANAPC16

KEGG Gene (Bos taurus):540089 ANAPC16

Monarch:540089 ANAPC16

NCBI Gene:540089 ANAPC16

Reference Transcript

Other Identifiers

540089

GO:0000775

GO:0000776

GO:0005634

GO:0005680

GO:0005694

GO:0005737

GO:0005829

GO:0007049

GO:0016567

GO:0036211

GO:0043226

GO:0051301

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)

Other forms of this molecule

ANAPC16 [nucleoplasm]

Inferred From

ANAPC16 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005226503.1, XP_005226504.1, XP_005226505.1, NP_001014960.1

OpenTargets

ENSG00000166295

Ensembl

ENSBTAP00000000186, ENSBTAG00000000162, ENSBTAT00000000186

VGNC

25883

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