Reactome | INTS2 [nucleoplasm]

INTS2 [nucleoplasm]

Stable Identifier

R-BTA-6807448

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

INTS2, E1BJI9

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Bos taurus)
        
        Integrator [nucleoplasm] (Bos taurus)
        
        INTS2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BJI9

Gene Names

INTS2

Reference Genes

ENSEMBL:ENSBTAG00000012070.6

Other Identifiers

534471

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0034472

GO:0043226

Participates

as a component of

Integrator [nucleoplasm] (Bos taurus)

Inferred From

INTS2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000108506

Ensembl

ENSBTAP00000016011, ENSBTAG00000012070, ENSBTAT00000016011

VGNC

30228