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26S proteasome [cytosol]
Stable Identifier
R-BTA-68819
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Stabilization of p53 (Bos taurus)
Autodegradation of the E3 ubiquitin ligase COP1 (Bos taurus)
Proteasome mediated degradation of COP1 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
p53-Independent G1/S DNA damage checkpoint (Bos taurus)
p53-Independent DNA Damage Response (Bos taurus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Bos taurus)
Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
G2/M Checkpoints (Bos taurus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Separation of Sister Chromatids (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Bos taurus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
The role of GTSE1 in G2/M progression after G2 checkpoint (Bos taurus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of Securin (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Bos taurus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Bos taurus)
Degradation multiubiquitinated Cyclin A (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
S Phase (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Ubiquitin-dependent degradation of Cyclin D (Bos taurus)
Proteasome mediated degradation of Cyclin D1 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
26S proteasome degrades Ub-NFE2L2 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
ub UBXN7 is degraded by the 26S proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Bos taurus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing-Cross presentation (Bos taurus)
Cross-presentation of soluble exogenous antigens (endosomes) (Bos taurus)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Proteasomal cleavage of substrate (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
Ubiquitinated IkB is degraded (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
26Sproteasome degrades K48polyUb-NIK (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of polyamines (Bos taurus)
Regulation of ornithine decarboxylase (ODC) (Bos taurus)
26S proteosome degrades ODC holoenzyme complex (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Metabolism of RNA (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Bos taurus)
AUF1:mRNA complex is destroyed (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
UCH proteinases (Bos taurus)
ADRM1 binds 26S proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
ADRM1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
ADRM1:26S proteaseome binds UCHL5 (Bos taurus)
ADRM1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
ADRM1:26S proteasome:UCHL5 [cytosol] (Bos taurus)
ADRM1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
ADRM1:26S proteaseome binds USP14 (Bos taurus)
ADRM1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
ADRM1:26S proteasome:USP14 [cytosol] (Bos taurus)
ADRM1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Neddylation (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
26S proteasome degrades Ub-NFE2L2 (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
ub UBXN7 is degraded by the 26S proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
Proteasome degrades polyubiquitinated PTEN (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
MAPK6 is degraded by the 26S proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
Degradation of GLI1 by the proteasome (Bos taurus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
GLI3 is processed to GLI3R by the proteasome (Bos taurus)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Hedgehog 'on' state (Bos taurus)
ub-GLI is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Hedgehog ligand biogenesis (Bos taurus)
Hh C-terminal fragments are degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
PCP/CE pathway (Bos taurus)
Asymmetric localization of PCP proteins (Bos taurus)
PRICKLE1 is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Degradation of AXIN (Bos taurus)
Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Degradation of DVL (Bos taurus)
Ubiquitinated DVL is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
misfolded CFTR is degraded by the 26S proteasome (Bos taurus)
26S proteasome [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
19S regulatory particle [cytosol]
(Bos taurus)
20S core particle [cytosol]
(Bos taurus)
Participates
as an input of
ADRM1 binds 26S proteasome (Bos taurus)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Bos taurus)
as a component of
ADRM1:26S proteasome [cytosol] (Bos taurus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Bos taurus)
as an output of
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)
Inferred From
26S proteasome [cytosol]
(Homo sapiens)
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