Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TP53 [nucleoplasm]
Stable Identifier
R-BTA-69488
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
P67939
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Stabilization of p53 (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
G2/M Checkpoints (Bos taurus)
G2/M DNA damage checkpoint (Bos taurus)
ATR phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Oxidative Stress Induced Senescence (Bos taurus)
MAPKAPK5 phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
DNA Repair (Bos taurus)
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Association with Co-factors (Bos taurus)
BANP binds TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53:BANP [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Regulation of TP53 Activity through Methylation (Bos taurus)
EHMT1:EHMT2 dimethylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Regulation of TP53 Activity through Phosphorylation (Bos taurus)
AMPK phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
ATM phosphorylates TP53 at S15 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
ATR phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
AURKA phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
CDK2 phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
CDK5 phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
MAPKAPK5 phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
NUAK1 phosphorylates TP53 (Bos taurus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TAF1 phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 binds HIPK1 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 Tetramer:HIPK1 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 binds STK11 and NUAK1 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53RK phosphorylates TP53 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Regulation of TP53 Expression (Bos taurus)
TP53 forms homotetramers (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Transcriptional regulation by RUNX3 (Bos taurus)
RUNX3 regulates CDKN1A transcription (Bos taurus)
RUNX3 binds TP53 (Bos taurus)
RUNX3:TP53 tetramer [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
PKR-mediated signaling (Bos taurus)
p-PKR dimer phosphorylates TP53 tetramer (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)
USP10,USP24,USP42:TP53 [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Bos taurus)
TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Bos taurus)
TP53 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:P67939
Reference Genes
BioGPS Gene:281542
ENSEMBL:ENSBTAG00000001069
KEGG:bta:281542
Monarch:281542
NCBI Gene:281542
UCSC:P67939
Reference Transcript
RefSeq:NM_174201.2
Other Identifiers
281542
GO:0000122
GO:0000423
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001046
GO:0001094
GO:0001227
GO:0001228
GO:0001701
GO:0001756
GO:0001836
GO:0002020
GO:0002039
GO:0002244
GO:0002309
GO:0002326
GO:0002360
GO:0002376
GO:0002931
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0003730
GO:0005507
GO:0005634
GO:0005654
GO:0005657
GO:0005667
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005813
GO:0005815
GO:0005829
GO:0005975
GO:0006091
GO:0006281
GO:0006289
GO:0006302
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006974
GO:0006977
GO:0006978
GO:0006979
GO:0006983
GO:0007005
GO:0007179
GO:0007265
GO:0007346
GO:0007369
GO:0007405
GO:0007406
GO:0007417
GO:0007507
GO:0007623
GO:0008104
GO:0008156
GO:0008283
GO:0008285
GO:0008340
GO:0009299
GO:0009303
GO:0009410
GO:0009411
GO:0009651
GO:0009792
GO:0010165
GO:0010332
GO:0010628
GO:0010629
GO:0010659
GO:0010666
GO:0012501
GO:0014009
GO:0016032
GO:0016071
GO:0016363
GO:0016604
GO:0016605
GO:0017053
GO:0019661
GO:0019899
GO:0021549
GO:0030154
GO:0030308
GO:0030330
GO:0030512
GO:0030971
GO:0031571
GO:0031625
GO:0032211
GO:0032991
GO:0033077
GO:0033209
GO:0034103
GO:0034644
GO:0035033
GO:0035264
GO:0035794
GO:0035861
GO:0036310
GO:0042127
GO:0042149
GO:0042771
GO:0042802
GO:0042826
GO:0042981
GO:0043065
GO:0043066
GO:0043073
GO:0043153
GO:0043226
GO:0043504
GO:0043516
GO:0043523
GO:0043525
GO:0045815
GO:0045861
GO:0045892
GO:0045893
GO:0045899
GO:0045930
GO:0045944
GO:0046677
GO:0046982
GO:0048144
GO:0048147
GO:0048512
GO:0048539
GO:0048568
GO:0048856
GO:0050731
GO:0050821
GO:0051087
GO:0051276
GO:0051402
GO:0051721
GO:0051726
GO:0060090
GO:0060218
GO:0060253
GO:0060333
GO:0060411
GO:0061024
GO:0061629
GO:0062100
GO:0065003
GO:0070059
GO:0070242
GO:0070243
GO:0070245
GO:0070266
GO:0071456
GO:0071466
GO:0071479
GO:0071480
GO:0071494
GO:0072089
GO:0072331
GO:0072332
GO:0072593
GO:0072717
GO:0090200
GO:0090398
GO:0090399
GO:0090403
GO:0097252
GO:0097371
GO:0097718
GO:0098772
GO:0140110
GO:0140296
GO:0140657
GO:0140677
GO:0140693
GO:1900119
GO:1901525
GO:1902108
GO:1902253
GO:1902749
GO:1902895
GO:1903451
GO:1903799
GO:1904024
GO:1905856
GO:1990144
GO:1990841
GO:2000269
GO:2000378
GO:2000379
GO:2000647
GO:2000772
GO:2000774
GO:2001244
Participates
as a component of
USP10,USP24,USP42:TP53 [nucleoplasm] (Bos taurus)
TP53 Tetramer [nucleoplasm] (Bos taurus)
as a member of
TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Bos taurus)
as an input of
TP53 forms homotetramers (Bos taurus)
Other forms of this molecule
TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
polySUMO2,3-K386-TP53 [nucleoplasm]
phospho-p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15-TP53 [nucleoplasm]
PolyUb-TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S37-TP53 [nucleoplasm]
phospho-p-T55-TP53 [nucleoplasm]
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
phospho-p-S15,S392-TP53 [nucleoplasm]
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
phospho-p-S315-TP53 [nucleoplasm]
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K120,p-S15,S20-TP53 [nucleoplasm]
Me2K-370,382-TP53 [nucleoplasm]
phospho-Me1-K372,p-S15,S20-TP53 [nucleoplasm]
phospho-Me-K382,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
phospho-MeK-370,p-S15,S20-TP53 [nucleoplasm]
Me2-K373-TP53 [nucleoplasm]
phospho-p-S392-TP53 [nucleoplasm]
Inferred From
TP53 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_776626.1
ENSEMBL
ENSBTAT00000001420
,
ENSBTAP00000001420
VGNC
36231
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text