Reactome | RPS27 [cytosol]

RPS27 [cytosol]

Stable Identifier

R-BTA-72361

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

RPS27, Q2KHT7

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Translation (Bos taurus)
  - Eukaryotic Translation Initiation (Bos taurus)
    - Cap-dependent Translation Initiation (Bos taurus)
      - Formation of a pool of free 40S subunits (Bos taurus)
        
        Release of 40S and 60S subunits from the 80S ribosome (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Bos taurus)
        
        The 60S subunit joins the translation initiation complex (Bos taurus)
        
        40S:Met-tRNAi:mRNA [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
        
        eIF5B:GTP is hydrolyzed and released (Bos taurus)
        
        80S:Met-tRNAi:mRNA [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
  - SRP-dependent cotranslational protein targeting to membrane (Bos taurus)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)
      - SRP:polypeptide+signal:ribosome [cytosol] (Bos taurus)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2KHT7

Gene Names

RPS27

Reference Genes

BioGPS Gene:615638 RPS27

ENSEMBL:ENSBTAG00000013866

KEGG Gene (Bos taurus):615638 RPS27

Monarch:615638 RPS27

NCBI Gene:615638 RPS27

Reference Transcript

RefSeq:NM_001098135.2 RPS27

Other Identifiers

615638

Bt.23383.1.S1_at

GO:0000028

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0008150

GO:0009058

GO:0022607

GO:0022618

GO:0022627

GO:0032991

GO:0034641

GO:0042254

GO:0043167

GO:0043226

GO:0046872

GO:0065003

Participant Of

hasMember

RPS27,RPS27L [cytosol]

Other forms of this molecule

RPS27 [nucleoplasm]

Inferred From

RPS27 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001091604.1

OpenTargets

ENSG00000177954

Ensembl

ENSBTAG00000013866, ENSBTAP00000018414, ENSBTAT00000018414

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