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About
What is Reactome ?
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Digital Preservation
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PIK3R2 [cytosol]
Stable Identifier
R-BTA-74791
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
PIK3R2, P23726
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Tie2 Signaling (Bos taurus)
Interaction of Tie2 and p85 of PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p85 bound to Tie2 [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
GPVI stimulates PI3K beta, gamma (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI3K alpha, beta, gamma [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K binds CD28 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K binds ICOS (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Recruitment of PI3K to plasma membrane (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K beta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K delta [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Interleukin-7 signaling (Bos taurus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Bos taurus)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Bos taurus)
PI3K regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Bos taurus)
PI3K regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
PI3K associates with phosphorylated GAB2 (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Role of phospholipids in phagocytosis (Bos taurus)
PI3K binds to p-6Y-SYK (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PIK3C(1) [cytosol] (Bos taurus)
PIK3CA:PIK3R2 [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PIK3CB:PIK3R2 [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PIK3CD:PIK3R2 [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
PIK3(2) [cytosol] (Bos taurus)
PIK3CA:PIK3R2 [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PIK3CB:PIK3R2 [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PIK3CD:PIK3R2 [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1,RAC2,RHOG activate PI3K (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS:GTP binds PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p21 RAS:GTP:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
G alpha (q) inhibits PI3K alpha (Bos taurus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
PI3K binds membrane-associated estrogen receptors (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PTK2 is recruited to methylated ESR1 (Bos taurus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Bos taurus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
Active ALK recruits PI3K (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3-kinase binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Direct recruitment of PI3K to p-KIT (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
p-AXL binds PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-regulatory subunit [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
CDC42 GTPase cycle (Bos taurus)
CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
CDC42 GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
RAC1 GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1 binds effectors at the plasma membrane (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
RAC2 GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC2 binds effectors at the plasma membrane (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RAC3 GTPase cycle (Bos taurus)
RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
RAC3 GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RHOA GTPase cycle (Bos taurus)
RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
RHOA GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RHOD GTPase cycle (Bos taurus)
RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
RHOD GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RHOF GTPase cycle (Bos taurus)
RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
RHOF GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RHOJ GTPase cycle (Bos taurus)
RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
RHOJ GAPs [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RHOU GTPase cycle (Bos taurus)
RHOU binds effectors at the plasma membrane (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RHOU:GTP:RHOU effectors [plasma membrane] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RND1 GTPase cycle (Bos taurus)
RND1 binds effectors (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RND1:GTP:RND1 effectors [plasma membrane] (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RND2 GTPase cycle (Bos taurus)
RND2 binds effectors (Bos taurus)
RND2 effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RND2:GTP:RND2 effectors [plasma membrane] (Bos taurus)
RND2 effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RND3 GTPase cycle (Bos taurus)
RND3 binds effectors (Bos taurus)
RND3 effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
RND3:GTP:RND3 effectors [plasma membrane] (Bos taurus)
RND3 effectors [cytosol] (Bos taurus)
PIK3R2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P23726
Gene Names
PIK3R2
Reference Genes
BioGPS Gene:282308 PIK3R2
ENSEMBL:ENSBTAG00000002350
KEGG Gene (Bos taurus):282308 PIK3R2
Monarch:282308 PIK3R2
NCBI Gene:282308 PIK3R2
Reference Transcript
RefSeq:NM_174576.2 PIK3R2
Other Identifiers
GO:0001678
GO:0005515
GO:0005634
GO:0005942
GO:0006351
GO:0006355
GO:0006629
GO:0006886
GO:0006913
GO:0006914
GO:0007165
GO:0008286
GO:0010506
GO:0015031
GO:0023052
GO:0032869
GO:0034976
GO:0042307
GO:0043226
GO:0043491
GO:0045944
GO:0046854
GO:0046935
GO:0098772
Participates
as a candidate of
RND2 effectors [cytosol] (Bos taurus)
RHOA GAPs [cytosol] (Bos taurus)
RND3 effectors [cytosol] (Bos taurus)
CDC42 GAPs [cytosol] (Bos taurus)
RAC2 GAPs [cytosol] (Bos taurus)
RHOD GAPs [cytosol] (Bos taurus)
RAC1 GAPs [cytosol] (Bos taurus)
RHOF GAPs [cytosol] (Bos taurus)
RHOJ GAPs [cytosol] (Bos taurus)
RAC3 GAPs [cytosol] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
RND1 effectors [cytosol] (Bos taurus)
PI3K regulatory subunits [cytosol] (Bos taurus)
PI3K-regulatory subunits [cytosol] (Bos taurus)
as a component of
PIK3CB:PIK3R2 [cytosol] (Bos taurus)
PIK3CD:PIK3R2 [cytosol] (Bos taurus)
PIK3CA:PIK3R2 [cytosol] (Bos taurus)
as a member of
PI3K-regulatory subunit [cytosol] (Bos taurus)
Other forms of this molecule
PIK3R2 [cytosol]
Inferred From
PIK3R2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_777001.1
OpenTargets
ENSG00000105647
Ensembl
ENSBTAG00000002350
,
ENSBTAT00000003033
,
ENSBTAP00000003033
VGNC
52862
PDB
3L4Q
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32871
1
PIK3CA [cytosol]
(R-BTA-74787)
0.524
3
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