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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
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Userguide
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Details Panel
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Analysis Data
Analysis Gene Expression
Species Comparison
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Citing us
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RAD50 [nucleoplasm]
Stable Identifier
R-BTA-75160
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
RAD50, G3X6W2
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
KAT5 acetylates ATM at DNA DSBs (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
KAT5 acetylates ATM at shortened telomeres (Bos taurus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN activates ATM (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN bound to shortened telomeres activates ATM (Bos taurus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex binds DNA double strand breaks (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex binds shortened telomeres (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex bound to DNA ends recruits ATM (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex bound to shortened telomeres recruits ATM (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
Shortened telomere:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA Repair (Bos taurus)
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM phosphorylates EYA1-4 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM phosphorylates HERC2 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM phosphorylates MDC1 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM phosphorylates NBN (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM phosphorylates WHSC1 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
ATM recognizes H2AFX-Nucleosomes (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
KDM4A,B bind H4K20Me2 (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MDC1 associates with gamma-H2AFX at nuclear foci (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Sensing of DNA Double Strand Breaks (Bos taurus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
RAD50:MRE11A [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Formation of RAD50:MRE11 complex (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
RAD50:MRE11A [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
KAT5 acetylates ATM at DNA DSBs (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN activates ATM (Bos taurus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex binds DNA double strand breaks (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex bound to DNA ends recruits ATM (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
ATM phosphorylates RBBP8 (Bos taurus)
DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Initial resection of double-strand break ends (Bos taurus)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Bos taurus)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
3' short overhanging ssDNA-DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex [nucleoplasm] (Bos taurus)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Bos taurus)
DNA DSBs:p-MRN [nucleoplasm] (Bos taurus)
p-MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
HDR through MMEJ (alt-NHEJ) (Bos taurus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
LIG3 ligates remaining SSBs in MMEJ (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN complex binds RBBP8 (Bos taurus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
DNA DSBs:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Bos taurus)
MRN [nucleoplasm] (Bos taurus)
RAD50 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:G3X6W2
Gene Names
RAD50
Reference Genes
BioGPS Gene:788127 RAD50
ENSEMBL:ENSBTAG00000011252
KEGG Gene (Bos taurus):788127 RAD50
Monarch:788127 RAD50
NCBI Gene:788127 RAD50
Reference Transcript
RefSeq:NM_001206868.1 RAD50
Other Identifiers
788127
Bt.27405.1.S1_at
Bt.27405.2.S1_at
GO:0000003
GO:0000014
GO:0000166
GO:0000228
GO:0000722
GO:0000723
GO:0000784
GO:0000790
GO:0000794
GO:0003674
GO:0003677
GO:0003678
GO:0003691
GO:0004017
GO:0004386
GO:0004518
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005694
GO:0006259
GO:0006281
GO:0006950
GO:0006974
GO:0007004
GO:0007049
GO:0008150
GO:0008408
GO:0009058
GO:0016233
GO:0016301
GO:0016787
GO:0016887
GO:0030870
GO:0032508
GO:0032991
GO:0034641
GO:0035861
GO:0042592
GO:0043047
GO:0043167
GO:0043226
GO:0044281
GO:0046872
GO:0046940
GO:0051276
GO:0051880
GO:0070192
GO:0090305
Participant Of
input
Formation of RAD50:MRE11 complex
hasComponent
MRN [nucleoplasm]
p-MRN [nucleoplasm]
RAD50:MRE11A [nucleoplasm]
Inferred From
RAD50 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_001193797.1
OpenTargets
ENSG00000113522
Ensembl
ENSBTAT00000014945
,
ENSBTAG00000011252
,
ENSBTAP00000014945
VGNC
52870
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