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TYK2 [cytosol]
Stable Identifier
R-BTA-877348
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
TYK2, F1MCX4
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Activation of JAK kinases (Bos taurus)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IFNAR1:TYK2:TYK2 inhibitors [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Recruitment of IFNAR1 (Bos taurus)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IFNAR1:TYK2:TYK2 inhibitors [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Regulation of IFNA signaling (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-12 family signaling (Bos taurus)
Interleukin-23 signaling (Bos taurus)
Interleukin-23 binds interleukin-23 receptor (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-27 signaling (Bos taurus)
Interleukin-27 binds Interleukin-27 receptor (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-35 Signalling (Bos taurus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-20 family signaling (Bos taurus)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Bos taurus)
IL10RB:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-4 and Interleukin-13 signaling (Bos taurus)
IL13RA1 binds TYK2 (Bos taurus)
IL13RA1:TYK2 [plasma membrane] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
IL-6-type cytokine receptor ligand interactions (Bos taurus)
JAKs bind LIFR (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
JAKs:LIFR [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)
JAKs:LIFR [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
OSM:OSMR,LIFR [plasma membrane] (Bos taurus)
JAKs:LIFR [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)
LIF,OSM receptor complex:gp130 [plasma membrane] (Bos taurus)
OSM:OSMR,LIFR [plasma membrane] (Bos taurus)
JAKs:LIFR [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
OSM:OSMR,LIFR [plasma membrane] (Bos taurus)
JAKs:LIFR [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
Interleukin-6 signaling (Bos taurus)
Assembly of hexameric IL-6 receptor (Bos taurus)
IL6 receptor hexamer:JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
JAK activation (Bos taurus)
IL6 receptor hexamer:JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
TYK2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MCX4
Gene Names
TYK2
Reference Genes
BioGPS Gene:512484 TYK2
ENSEMBL:ENSBTAG00000011698
Monarch:512484 TYK2
NCBI Gene:512484 TYK2
Reference Transcript
RefSeq:XM_005208738.3 TYK2
RefSeq:XM_005208739.3 TYK2
RefSeq:XM_010806821.2 TYK2
RefSeq:XM_005208737.3 TYK2
RefSeq:XM_010806820.2 TYK2
RefSeq:XM_010806822.2 TYK2
Other Identifiers
512484
GO:0000166
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005856
GO:0006464
GO:0006468
GO:0007165
GO:0008150
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0035556
GO:0043167
GO:0043226
Participates
as a component of
IFNAR1:TYK2 [plasma membrane] (Bos taurus)
IL10RB:TYK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
IL13RA1:TYK2 [plasma membrane] (Bos taurus)
as an input of
IL13RA1 binds TYK2 (Bos taurus)
as a candidate of
JAK1, JAK2, (TYK2) [cytosol] (Bos taurus)
Other forms of this molecule
phospho-TYK2 [cytosol]
phospho-TYK2 [cytosol]
phospho-TYK2 [cytosol]
phospho-TYK2 [cytosol]
Inferred From
TYK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_010805124.1
,
XP_010805122.1
,
XP_005208794.1
,
XP_010805123.1
,
XP_005208796.1
,
XP_005208795.1
OpenTargets
ENSG00000105397
Ensembl
ENSBTAG00000011698
,
ENSBTAT00000015532
,
ENSBTAP00000015532
VGNC
36548
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