Reactome | FBXL18 [cytosol]

FBXL18 [cytosol]

Stable Identifier

R-BTA-8854063

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

FBXL18, F6PQR5

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - Mitotic G2-G2/M phases (Bos taurus)
    - G2/M Transition (Bos taurus)
      - FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Bos taurus)
        
        SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
        
        SKP1:CUL1:RBX1:FBXL18 [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXL18 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F6PQR5

Gene Names

FBXL18

Reference Genes

BioGPS Gene:789838 FBXL18

ENSEMBL:ENSBTAG00000010264.5

KEGG Gene (Bos taurus):789838 FBXL18

Monarch:789838 FBXL18

NCBI Gene:789838 FBXL18

Reference Transcript

Other Identifiers

789838

GO:0005515

GO:0019005

GO:0030163

GO:0031146

Participates

as a component of

SKP1:CUL1:RBX1:FBXL18 [cytosol] (Bos taurus)

as a member of

F-box protein [cytosol] (Bos taurus)

Inferred From

FBXL18 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003584105.2, XP_002698206.3

OpenTargets

ENSG00000155034

Ensembl

ENSBTAP00000043924, ENSBTAG00000010264, ENSBTAT00000046646

VGNC

52774

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