Reactome | M6PR [plasma membrane]

M6PR [plasma membrane]

Stable Identifier

R-BTA-8864564

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

M6PR, P11456

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - AP-2 directly binds some endocytic cargo (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        M6PR [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:P11456

Gene Names

M6PR

Reference Genes

BioGPS Gene:281291 M6PR

ENSEMBL:ENSBTAG00000018207

KEGG:bta:281291 M6PR

Monarch:281291 M6PR

NCBI Gene:281291 M6PR

UCSC:P11456 M6PR

Reference Transcript

RefSeq:NM_175779.3 M6PR

Other Identifiers

281291

Bt.5032.1.S1_at

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005794

GO:0005802

GO:0006622

GO:0006886

GO:0007041

GO:0012505

GO:0016020

GO:0019904

GO:0031410

GO:0033299

GO:0043226

GO:0043231

GO:0048471

GO:1905394

Participates

as a member of

AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)

Other forms of this molecule

M6PR [clathrin-coated endocytic vesicle membrane]

M6PR [Golgi membrane]

M6PR [lysosomal membrane]

M6PR [trans-Golgi network membrane]

M6PR [transport vesicle]

Inferred From

M6PR [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_786973.1

ENSEMBL

ENSBTAT00000024233, ENSBTAG00000018207, ENSBTAP00000024233, ENSBTAP00000088610, ENSBTAT00000091971

VGNC

31125

PDB

3K41, 2RL7, 2RL9, 2RL8, 3K43, 1C39, 3K42, 3CY4, 2RLB, 1KEO, 1M6P

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