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COMMDs:CCDC22 [cytosol]
Stable Identifier
R-BTA-8955646
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
COMMDs:CCDC22 [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CCDC22 [cytosol]
(Bos taurus)
COMMDs [cytosol]
(Bos taurus)
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
as an input of
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
Inferred From
COMMDs:CCDC22 [cytosol]
(Homo sapiens)
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