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phospho-BRCA1 [nucleoplasm]
Stable Identifier
R-BTA-9707290
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1, F1MYX8
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G2/M Checkpoints (Bos taurus)
G2/M DNA damage checkpoint (Bos taurus)
CHEK2 is recruited to DNA DSBs (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
DNA Repair (Bos taurus)
DNA Double-Strand Break Repair (Bos taurus)
DNA Double Strand Break Response (Bos taurus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
CHEK2 is recruited to DNA DSBs (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
CHEK2 phosphorylates BRCA1 (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Bos taurus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Bos taurus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Bos taurus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
phospho-BRCA1 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MYX8
Gene Names
BRCA1
Reference Genes
ENSEMBL:ENSBTAG00000022520.5
Other Identifiers
353120
GO:0000724
GO:0003677
GO:0003824
GO:0004842
GO:0005634
GO:0005694
GO:0005737
GO:0005886
GO:0006281
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006629
GO:0006631
GO:0006633
GO:0006974
GO:0007049
GO:0008270
GO:0009048
GO:0016740
GO:0031436
GO:0035066
GO:0035067
GO:0036211
GO:0043009
GO:0043226
GO:0043231
GO:0045717
GO:0045944
GO:0046872
GO:0048856
GO:0051865
GO:0070531
GO:0085020
GO:0140096
Participates
as a component of
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Bos taurus)
Other forms of this molecule
BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
Inferred From
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K6-PolyUb [nucleoplasm]) at unknown position
Modification
K6polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
O-phospho-L-serine at 1387 (in Homo sapiens)
Coordinate
1387
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1423 (in Homo sapiens)
Coordinate
1423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1457 (in Homo sapiens)
Coordinate
1457
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1524 (in Homo sapiens)
Coordinate
1524
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000012048
Ensembl
ENSBTAP00000011616
,
ENSBTAG00000022520
,
ENSBTAT00000011616
VGNC
55781
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