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About
What is Reactome ?
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Ub [cytosol]
Stable Identifier
R-CEL-113595
Type
Set [DefinedSet]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
ubiquitin
Locations in the PathwayBrowser
Expand all
Autophagy (Caenorhabditis elegans)
Macroautophagy (Caenorhabditis elegans)
Selective autophagy (Caenorhabditis elegans)
Aggrephagy (Caenorhabditis elegans)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Parkin binds Ub:UBE2N:UBE2V1 (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Parkin transfers Ub to misfolded proteins (Caenorhabditis elegans)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub-Misfolded Proteins [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Caenorhabditis elegans)
PolyUb-Misfolded Proteins [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
PolyUb-Misfolded Proteins [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
PolyUb-Misfolded Proteins [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub-Misfolded Proteins [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Mitophagy (Caenorhabditis elegans)
PINK1-PRKN Mediated Mitophagy (Caenorhabditis elegans)
PRKN ubiquitinates MOM substrates (Caenorhabditis elegans)
Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Caenorhabditis elegans)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Proteasome-mediated degradation of PolyUb-FBXL7 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
SCF-FBXL18 ubiquitinates FBXL7 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-p-8S,3T-BORA [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
S Phase (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ubiquitinated Cdc6 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Orc1 removal from chromatin (Caenorhabditis elegans)
Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitin-dependent degradation of Cyclin D (Caenorhabditis elegans)
Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
CUL3:RBX1 ubiquitinates KEAP1 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
UBE2D1,2,3:Ubiquitin [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
DNA Replication (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ubiquitinated Cdc6 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Orc1 removal from chromatin (Caenorhabditis elegans)
Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
Regulation of RUNX2 expression and activity (Caenorhabditis elegans)
STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Transcriptional regulation by RUNX3 (Caenorhabditis elegans)
Regulation of RUNX3 expression and activity (Caenorhabditis elegans)
Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
E1 mediated ubiquitin activation (Caenorhabditis elegans)
E1 bound ubiquitin [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
Ubiquitin:E2 conjugating enzymes [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitin:E2 conjugating enzymes [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Polyubiquitination of substrate (Caenorhabditis elegans)
E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
Ub:substrate [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitin:E2 conjugating enzymes [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Proteasomal cleavage of substrate (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
Ubiquitin:E2 conjugating enzymes [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
Ub:substrate [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)
E1 bound ubiquitin [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitin:E2 conjugating enzymes [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
Co-inhibition by PD-1 (Caenorhabditis elegans)
Regulation of PD-L1(CD274) expression (Caenorhabditis elegans)
Regulation of PD-L1(CD274) Post-translational modification (Caenorhabditis elegans)
SPOP-mediated proteasomal degradation of PD-L1(CD274) (Caenorhabditis elegans)
CD274 ubiquitination by SPOP:CUL3:RBX1 complex (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
SPOP-mediated degradation of CD274 by 26S Proteosome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Cytosolic sensors of pathogen-associated DNA (Caenorhabditis elegans)
Regulation of innate immune responses to cytosolic DNA (Caenorhabditis elegans)
DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Caenorhabditis elegans)
Negative regulators of DDX58/IFIH1 signaling (Caenorhabditis elegans)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Caenorhabditis elegans)
Calnexin/calreticulin cycle (Caenorhabditis elegans)
ER Quality Control Compartment (ERQC) (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Deubiquitination (Caenorhabditis elegans)
Ovarian tumor domain proteases (Caenorhabditis elegans)
OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
UCH proteinases (Caenorhabditis elegans)
UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)
UCHL1,UCHL3:Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-specific processing proteases (Caenorhabditis elegans)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
USP5 cleaves polyubiquitin (Caenorhabditis elegans)
USP5:Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Neddylation (Caenorhabditis elegans)
26S proteasome degrades HIFalpha (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
UBE2D1,2,3:Ubiquitin [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Protein ubiquitination (Caenorhabditis elegans)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
UBA1 conjugates ubiquitin to UBA1 in the cytosol (Caenorhabditis elegans)
Ub-Cys632-UBA1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Caenorhabditis elegans)
Ub-Cys632-UBA1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub:E2 (UBA1 substrate) [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-Cys632-UBA1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Caenorhabditis elegans)
Ub-Cys632-UBA1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Translation (Caenorhabditis elegans)
Ribosome-associated quality control (Caenorhabditis elegans)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Caenorhabditis elegans)
LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Caenorhabditis elegans)
Ub:UBE2D1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Caenorhabditis elegans)
ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Caenorhabditis elegans)
Ub:UBE2D1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Caenorhabditis elegans)
Ub:UBE2D1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Caenorhabditis elegans)
Ub:UBE2D1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Caenorhabditis elegans)
Ub:UBE2D1 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Death Receptor Signaling (Caenorhabditis elegans)
TNF signaling (Caenorhabditis elegans)
Regulation of TNFR1 signaling (Caenorhabditis elegans)
MIB2 ubiquitinates CYLD at K338, K530 (Caenorhabditis elegans)
MIB2:CYLD:UBE2D2 [cytosol] (Caenorhabditis elegans)
Ub:UBE2D2 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN stability and activity (Caenorhabditis elegans)
MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
RNF146 polyubiquitinates PARylated PTEN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
TRIM27 polyubiquitinates PTEN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
BRAP autoubiquitinates (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by Hedgehog (Caenorhabditis elegans)
Hedgehog ligand biogenesis (Caenorhabditis elegans)
SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Caenorhabditis elegans)
CBL autoubiquitinates (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
CBL ubiquitinates Sprouty (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Caenorhabditis elegans)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by ERBB4 (Caenorhabditis elegans)
Downregulation of ERBB4 signaling (Caenorhabditis elegans)
ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR2 (Caenorhabditis elegans)
Negative regulation of FGFR2 signaling (Caenorhabditis elegans)
CBL ubiquitinates FRS2 and FGFR2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by FGFR3 (Caenorhabditis elegans)
Negative regulation of FGFR3 signaling (Caenorhabditis elegans)
CBL ubiquitinates FRS2 and FGFR3 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
CBL monoubiquitinates activated MET (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
TGF-beta receptor signaling activates SMADs (Caenorhabditis elegans)
Downregulation of TGF-beta receptor signaling (Caenorhabditis elegans)
Degradation of TGF-beta receptor complex (Caenorhabditis elegans)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Degradation of ubiquitinated SMAD2 (Caenorhabditis elegans)
Ub-SMAD2 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Degradation of ubiquitinated SMAD3 (Caenorhabditis elegans)
Ub-SMAD3 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-SMAD3 [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Signaling by WNT (Caenorhabditis elegans)
Degradation of beta-catenin by the destruction complex (Caenorhabditis elegans)
Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
Degradation of AXIN (Caenorhabditis elegans)
RNF146 ubiquitinates ADP-ribosylated AXIN (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-RibC-AXIN is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Degradation of DVL (Caenorhabditis elegans)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Stimuli-sensing channels (Caenorhabditis elegans)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Iron uptake and transport (Caenorhabditis elegans)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Clathrin recruits PIK3C2A (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub [cytosol] (Caenorhabditis elegans)
Participants
members
UBB(1-76) [cytosol]
(Caenorhabditis elegans)
UBB(77-152) [cytosol]
(Caenorhabditis elegans)
UBB(153-228) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(1-76) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(77-152) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(153-228) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(229-304) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(305-380) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(381-456) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(457-532) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(533-608) [cytosol]
(Caenorhabditis elegans)
Homologues of UBC(609-684) [cytosol]
(Caenorhabditis elegans)
Participates
as a component of
Ub:PEX5L [cytosol] (Caenorhabditis elegans)
USP5:Ub [cytosol] (Caenorhabditis elegans)
UCHL1,UCHL3:Ub [cytosol] (Caenorhabditis elegans)
Ub:E2 (UBA1 substrate) [cytosol] (Caenorhabditis elegans)
Ub-Cys632-UBA1 [cytosol] (Caenorhabditis elegans)
Ub:UBE2N [cytosol] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Caenorhabditis elegans)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Caenorhabditis elegans)
K63 linked polyubiquitin chain [cytosol] (Caenorhabditis elegans)
Ub:UBE2D2 [cytosol] (Caenorhabditis elegans)
Ub:UBE2D1 [cytosol] (Caenorhabditis elegans)
polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol] (Caenorhabditis elegans)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Caenorhabditis elegans)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Caenorhabditis elegans)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Caenorhabditis elegans)
Ub-p-8S,3T-BORA [cytosol] (Caenorhabditis elegans)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
ubiquitinated Cdc6 [cytosol] (Caenorhabditis elegans)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Caenorhabditis elegans)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Caenorhabditis elegans)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol] (Caenorhabditis elegans)
Ub:UBE2N:UBE2V1 [cytosol] (Caenorhabditis elegans)
Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Caenorhabditis elegans)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Caenorhabditis elegans)
Ub-SMAD3 [cytosol] (Caenorhabditis elegans)
Ub-SMAD2 [cytosol] (Caenorhabditis elegans)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Caenorhabditis elegans)
Ub:substrate [cytosol] (Caenorhabditis elegans)
Ubiquitin:E2 conjugating enzymes [cytosol] (Caenorhabditis elegans)
E1 bound ubiquitin [cytosol] (Caenorhabditis elegans)
UBE2D1,2,3:Ubiquitin [cytosol] (Caenorhabditis elegans)
Ub:UBE2L3 [cytosol] (Caenorhabditis elegans)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
as an input of
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)
SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)
TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)
CUL3:RBX1 ubiquitinates KEAP1 (Caenorhabditis elegans)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Caenorhabditis elegans)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)
DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)
CD274 ubiquitination by SPOP:CUL3:RBX1 complex (Caenorhabditis elegans)
CBL ubiquitinates FRS2 and FGFR3 (Caenorhabditis elegans)
CBL monoubiquitinates activated MET (Caenorhabditis elegans)
CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
CBL ubiquitinates Sprouty (Caenorhabditis elegans)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)
SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)
SCF-FBXL18 ubiquitinates FBXL7 (Caenorhabditis elegans)
CBL ubiquitinates FRS2 and FGFR2 (Caenorhabditis elegans)
STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)
ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)
STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)
E1 mediated ubiquitin activation (Caenorhabditis elegans)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)
TRIM27 polyubiquitinates PTEN (Caenorhabditis elegans)
RNF146 polyubiquitinates PARylated PTEN (Caenorhabditis elegans)
MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)
BRAP autoubiquitinates (Caenorhabditis elegans)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)
CBL autoubiquitinates (Caenorhabditis elegans)
RNF146 ubiquitinates ADP-ribosylated AXIN (Caenorhabditis elegans)
DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)
as an output of
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Caenorhabditis elegans)
OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)
USP5 cleaves polyubiquitin (Caenorhabditis elegans)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)
26S proteasome degrades HIFalpha (Caenorhabditis elegans)
misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)
26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)
Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
SPOP-mediated degradation of CD274 by 26S Proteosome (Caenorhabditis elegans)
Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)
Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
Proteasome-mediated degradation of PolyUb-FBXL7 (Caenorhabditis elegans)
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)
Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)
Proteasomal cleavage of substrate (Caenorhabditis elegans)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)
Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)
Ub-RibC-AXIN is degraded by the proteasome (Caenorhabditis elegans)
Inferred From
Ub [cytosol]
(Homo sapiens)
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