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skr-1 [cytosol]
Stable Identifier
R-CEL-174150
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
SKP1, G5ECU1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Caenorhabditis elegans)
Formation of the SCF-FBXL7 complex (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SCF-FBXL18 ubiquitinates FBXL7 (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)
SCF-FBXL7:AURKA [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SCF:FBXL7 binds AURKA (Caenorhabditis elegans)
SCF-FBXL7:AURKA [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Caenorhabditis elegans)
CUL1:FBXW11:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] (Caenorhabditis elegans)
CUL1:FBXW11:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)
CUL1:FBXW11:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] (Caenorhabditis elegans)
CUL1:FBXW11:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Polyubiquitination of substrate (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Neddylation (Caenorhabditis elegans)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by WNT (Caenorhabditis elegans)
Degradation of beta-catenin by the destruction complex (Caenorhabditis elegans)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Caenorhabditis elegans)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Caenorhabditis elegans)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
Transport of small molecules (Caenorhabditis elegans)
Iron uptake and transport (Caenorhabditis elegans)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:FBXL5 [cytosol] (Caenorhabditis elegans)
skr-1 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:G5ECU1
Gene Names
skr-1
Reference Genes
BioGPS Gene:172775 skr-1
CTD Gene:172775 skr-1
ENSEMBL:WBGene00004807
KEGG:cel:CELE_F46A9.5 skr-1
Monarch:172775 skr-1
NCBI Gene:172775 skr-1
UCSC:G5ECU1 skr-1
Wormbase:WBGene00004807
Wormbase:WBGene00004807 skr-1
Reference Transcript
RefSeq:NM_060112.8 skr-1
Other Identifiers
172775
GO:0005515
GO:0005634
GO:0005737
GO:0006511
GO:0007399
GO:0010629
GO:0010826
GO:0019005
GO:0030163
GO:0031146
GO:0031647
GO:0043065
GO:0043518
GO:0046660
GO:0048856
GO:0090128
GO:0097602
GO:1902230
GO:1905806
Participates
as a component of
NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Caenorhabditis elegans)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Caenorhabditis elegans)
SKP1:CUL1:FBXL5 [cytosol] (Caenorhabditis elegans)
SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
CUL1:FBXW11:SKP1 [cytosol] (Caenorhabditis elegans)
as an input of
Formation of the SCF-FBXL7 complex (Caenorhabditis elegans)
Other forms of this molecule
skr-1 [nucleoplasm]
Inferred From
SKP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_492513.1
ENSEMBL
F46A9.5.1
,
F46A9.5.1
,
WBGene00004807
PRO
G5ECU1
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93794 SEL10
0.778
5
UniProt:Q18223 FBSP1
0.712
4
UniProt:P91305 P91305
0.621
3
UniProt:O16525 O16525
0.621
5
UniProt:Q17962
5
FBXO2 [cytosol]
(R-CEL-976044)
FBXO6 [cytosol]
(R-CEL-391296)
FBXO17 [cytosol]
(R-CEL-976036)
FBXO27 [cytosol]
(R-CEL-976039)
FBXO44 [cytosol]
(R-CEL-976031)
0.621
3
UniProt:Q2YS44 Q2YS44
0.488
2
UniProt:Q2YS43 Q2YS43
0.488
4
UniProt:O17198 O17198
0.488
4
UniProt:O01606 O01606
0.488
2
UniProt:Q20775 Q20775
0.488
2
UniProt:Q94251
1
dre-1 [cytosol]
(R-CEL-8955092)
0.488
3
UniProt:Q9NDU9 Q9NDU9
0.488
2
UniProt:G5EDX9 G5EDX9
0.488
4
UniProt:G5EGS1 G5EGS1
0.488
2
UniProt:O45285 O45285
0.488
2
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