Reactome | ocrl-1 [cytosol]

ocrl-1 [cytosol]

Stable Identifier

R-CEL-1806196

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

OCRL, O17590

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
      - SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)
      - SYNJs,OCRL [cytosol] (Caenorhabditis elegans)
        
        ocrl-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O17590

Gene Names

ocrl-1

Reference Genes

BioGPS Gene:172822 ocrl-1

ENSEMBL:WBGene00007620

Monarch:172822 ocrl-1

NCBI Gene:172822 ocrl-1

UCSC:O17590 ocrl-1

Wormbase:WBGene00007620

Wormbase:WBGene00007620 ocrl-1

Reference Transcript

Other Identifiers

172822

GO:0004439

GO:0005737

GO:0005768

GO:0006629

GO:0007165

GO:0016020

GO:0016787

GO:0016791

GO:0030670

GO:0031410

GO:0031901

GO:0043005

GO:0046856

Participates

as a candidate of

as a member of

Other forms of this molecule

ocrl-1 [Golgi membrane]

ocrl-1 [cytoplasmic vesicle membrane]

ocrl-1 [plasma membrane]

Inferred From

OCRL/INPP5E [cytosol] (Homo sapiens)

OCRL [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001122420.1, NP_001361846.1

ENSEMBL

C16C2.3a.1, C16C2.3a.2, C16C2.3a.2, C16C2.3a.1, WBGene00007620