Reactome | AP2A2(1-939) [cytosol]

AP2A2(1-939) [cytosol]

Stable Identifier

R-CEL-182155

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q22601

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - EPH-ephrin mediated repulsion of cells (Caenorhabditis elegans)
        
        Clathrin internalises EPH:EFN complexes (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        AP2:chlorpromazine [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - AP2 binds chlorpromazine (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        AP2:chlorpromazine [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
      - AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)
        
        p-T156 AP-2 Complex [cytosol] (Caenorhabditis elegans)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)
        
        AP2A2(1-939) [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q22601

Reference Genes

ENSEMBL:WBGene00000161

UCSC:Q22601

Wormbase:WBGene00000161

Reference Transcript

RefSeq:NM_077171.6

Other Identifiers

174879_at

181163

18615955

189016_at

A_12_P103929

CE28680

CE_WBGene00000161_A

CE_WBGene00000161_B

CE_WBGene00000161_C

CGZ0035679

GO:0005886

GO:0006886

GO:0015031

GO:0016192

GO:0030117

GO:0030122

GO:0030131

GO:0031410

GO:0035615

GO:0043226

GO:0060090

GO:0072583

T20B5.1

T20B5.1_2565-2624_0.951_2_B

T20B5.1_2647-2706_0.958_1_A

T20B5.1_2740-2799_0.945_3_C

T20B5_1P01585

T20B5_1P02512

T20B5_1P02685

WBGene00000161

cea2.p.154371

Participates

as a member of

Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

AP2A1 [endolysosome membrane]

AP2A2(1-939) [endolysosome membrane]

AP2A2(1-939) [ficolin-1-rich granule membrane]

AP2A2(1-939) [secretory granule membrane]

AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]

AP2A1 [clathrin-coated endocytic vesicle membrane]

AP2A1 [cytosol]

AP2A2(1-939) [plasma membrane]

AP2A1 [plasma membrane]

Inferred From

AP2A2(1-939) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_509572.1

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