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RHOA [plasma membrane]
Stable Identifier
R-CEL-194510
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
plasma membrane
Synonyms
Q22038
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHA-mediated growth cone collapse (Caenorhabditis elegans)
NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D induced cell migration and growth-cone collapse (Caenorhabditis elegans)
Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RhoA,B,C:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by ROBO receptors (Caenorhabditis elegans)
SLIT2:ROBO1 increases RHOA activity (Caenorhabditis elegans)
MYO9B inactivates RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Neutrophil degranulation (Caenorhabditis elegans)
Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)
Ficolin-rich granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)
Secretory granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Death Receptor Signaling (Caenorhabditis elegans)
p75 NTR receptor-mediated signalling (Caenorhabditis elegans)
p75NTR regulates axonogenesis (Caenorhabditis elegans)
Axonal growth inhibition (RHOA activation) (Caenorhabditis elegans)
RhoA is activated by nucleotide exchange and inhibits axonal growth (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (12/13) signalling events (Caenorhabditis elegans)
GEFs activate RhoA,B,C (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RhoA,B,C:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p115-RhoGEF activation of RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Caenorhabditis elegans)
ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
ERBB2 Regulates Cell Motility (Caenorhabditis elegans)
MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)
RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
PI3K/AKT activation (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ROCK1,ROCK2 are activated (Caenorhabditis elegans)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate Formins (Caenorhabditis elegans)
DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPases Activate ROCKs (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPases Activate Rhotekin and Rhophilins (Caenorhabditis elegans)
RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)
RHOA:GTP:RTKN [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN:LIN7B [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)
RHOA:GTP:RTKN [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN:TAX1BP3 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPases activate PKNs (Caenorhabditis elegans)
PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RHOA GTPase cycle (Caenorhabditis elegans)
GDIs block activation of RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA GEFs activate RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q22038
Reference Genes
BioGPS Gene:178458
ENSEMBL:WBGene00004357
KEGG Gene (Caenorhabditis elegans):CELE_Y51H4A.3
Monarch:178458
NCBI Gene:178458
UCSC:Q22038
Wormbase:WBGene00004357
Reference Transcript
RefSeq:NM_070558.6
Other Identifiers
173426_at
174946_at
178458
18558739
193142_s_at
A_12_P108693
CE25369
CE_WBGene00004357_A
CGZ0048016
GO:0003824
GO:0003924
GO:0005525
GO:0007264
GO:0016787
GO:0023052
WBGene00004357
Y51H4A.3
Y51H4A.3_267-326_0.923_15_C
Y51H4A.3_369-428_0.949_2_B
Y51H4A.3_405-464_0.949_1_A
Y51H4A_3P00063
Y51H4A_3P00187
Y51H4A_3P00480
cea2.c.31959
Participates
as a member of
Ficolin-rich granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
Secretory granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
as a component of
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
as an input of
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
Other forms of this molecule
RHOD [mitochondrial outer membrane]
RHOD [cytosol]
RHOD [plasma membrane]
RHOD [Golgi membrane]
RHOA [ficolin-1-rich granule membrane]
RHOF [plasma membrane]
RHOF [secretory granule membrane]
RHOA [secretory granule membrane]
RHOD [endosome membrane]
RHOB [endosome membrane]
RHOB [cytosol]
RHOA [endoplasmic reticulum membrane]
RHOA [cytosol]
RHOA [cell junction]
RHOB [plasma membrane]
Inferred From
RHOA [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_502959.1
PRO
Q22038
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P5Z2 PKN3
2
p-T718-PKN3 [cytosol]
(R-HSA-5623654)
PKN3 [cytosol]
(R-HSA-5623611)
0.544
2
UniProt:Q28021 ROCK2
1
ROCK2 [cytosol]
(R-BTA-419911)
0.508
2
UniProt:O44770 KATIP
0.488
2
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