Reactome | aakb-2 [cytosol]

aakb-2 [cytosol]

Stable Identifier

R-CEL-200413

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

PRKAB2, Q9NAH7

Locations in the PathwayBrowser

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Autophagy (Caenorhabditis elegans)

- Macroautophagy (Caenorhabditis elegans)
  - AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - ULK complex translocates to the ER (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
        
        SESN1,2,3 bind AMPK (Caenorhabditis elegans)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)
        
        aakb-2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9NAH7

Gene Names

aakb-2

Reference Genes

BioGPS Gene:176552 aakb-2

ENSEMBL:WBGene00012928

Monarch:176552 aakb-2

NCBI Gene:176552 aakb-2

UCSC:Q9NAH7 aakb-2

Wormbase:WBGene00012928

Reference Transcript

RefSeq:NM_067045.1 aakb-2

Other Identifiers

176552

18517459

185679_at

A_12_P113294

CE22044

CE_WBGene00012928_A

CE_WBGene00012928_B

CE_WBGene00012928_C

CGZ0046897

GO:0005515

WBGene00012928

Y47D3A.15

Y47D3A.15_293-352_0.912_2_B

Y47D3A.15_364-423_0.927_1_A

Y47D3A.15_419-478_0.909_3_C

Y47D3A_15P00028

Y47D3A_15P00232

Y47D3A_15P00733

cea2.p.77341

Participates

as a member of

Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

aakb-2 [nucleoplasm]

Inferred From

PRKAB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_499446.1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q95ZQ4	5	PRKAA2 [nucleoplasm] (R-CEL-163682) PRKAA1 [cytosol] (R-CEL-380935-2) phospho-p-T183-PRKAA1 [cytosol] (R-CEL-380964-2) phospho-p-T172-PRKAA2 [cytosol] (R-CEL-200417) PRKAA2 [cytosol] (R-CEL-200405)	0.488	4

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