Reactome | col-135 [extracellular region]

col-135 [extracellular region]

Stable Identifier

R-CEL-2127337-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

extracellular region

Synonyms

COL2A1(182-1241), Q86D04

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - NCAM signaling for neurite out-growth (Caenorhabditis elegans)
      - NCAM1 interactions (Caenorhabditis elegans)
        
        Interaction of NCAM1 with collagens (Caenorhabditis elegans)
        
        Collagens [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        NCAM-1:Collagen complex [plasma membrane] (Caenorhabditis elegans)
        
        Collagens [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)

Extracellular matrix organization (Caenorhabditis elegans)

- Collagen formation (Caenorhabditis elegans)
  - Assembly of collagen fibrils and other multimeric structures (Caenorhabditis elegans)
    - Collagen XI cross-links with collagen II (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - Collagen type XI fibril:Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - Formation of collagen fibres (Caenorhabditis elegans)
      - Collagen fibres [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibre [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Collagen type XI fibre [extracellular region] (Caenorhabditis elegans)
        
        Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - Collagen fibrils [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - Formation of collagen fibrils (Caenorhabditis elegans)
      - Collagen fibrils [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - Tropocollagens [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - Type X collagen associates with collagen type II fibrils (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - Collagen type X:type II fibrils [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
  - Collagen biosynthesis and modifying enzymes (Caenorhabditis elegans)
    - Removal of fibrillar collagen C-propeptides (Caenorhabditis elegans)
      - Tropocollagens [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
- Degradation of the extracellular matrix (Caenorhabditis elegans)
  - Collagen degradation (Caenorhabditis elegans)
    - Collagen type II degradation by MMP1,3,8,13,PRSS2 (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - Collagen type II degradation by MMP15 (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
- FN1 binds Collagen types I-V, VII (Caenorhabditis elegans)
  - Collagen types I-V, VII [extracellular region] (Caenorhabditis elegans)
    - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
      - Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Caenorhabditis elegans)
    - Collagen types I-V, VII [extracellular region] (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
- Integrin cell surface interactions (Caenorhabditis elegans)
  - Collagen type II binds integrin alpha10beta1 (Caenorhabditis elegans)
    - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
      - Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
- Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Caenorhabditis elegans)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Caenorhabditis elegans)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
        
        Collagen type XI fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type XI [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Caenorhabditis elegans)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Caenorhabditis elegans)
      - Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Caenorhabditis elegans)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by PDGF (Caenorhabditis elegans)
    - PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)
      - Extracellular matrix ligands [extracellular region] (Caenorhabditis elegans)
        
        Collagens [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)
      - PDGF A and B chains:ECM complex [extracellular region] (Caenorhabditis elegans)
        
        Extracellular matrix ligands [extracellular region] (Caenorhabditis elegans)
        
        Collagens [extracellular region] (Caenorhabditis elegans)
        
        Collagen type II fibril [extracellular region] (Caenorhabditis elegans)
        
        Tropocollagen type II [extracellular region] (Caenorhabditis elegans)
        
        Collagen alpha-1(II) chains [extracellular region] (Caenorhabditis elegans)
        
        Homologues of COL2A1(182-1241) [extracellular region] (Caenorhabditis elegans)
        
        col-135 [extracellular region] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q86D04

Gene Names

col-135

Reference Genes

ENSEMBL:WBGene00000708

Wormbase:WBGene00000708

Other Identifiers

18554854

3565413

A_12_P115823

CAD89749

CE33807

CE_WBGene00000708_A

CGZ0030330

col-135

EntrezGene:3565413

EntrezGene:col-135

GO:0003674

GO:0005198

GO:0005201

GO:0005575

GO:0005576

GO:0005581

GO:0005615

GO:0008150

GO:0030198

GO:0031012

GO:0032991

IPR008160

M199.5

M199.5_1840-1899_0.961_1_A

M199.5a

M199.5a.1

M199_5P00650

M199_5P01064

M199_5P01871

NP_001255859

PF01391

UPI0000190AF6

WBGene00000708

Participant Of

hasMember

Homologues of COL2A1(182-1241) [extracellular region]

Other forms of this molecule

col-135 [endoplasmic reticulum lumen]

col-135 [extracellular region]

Inferred From

COL2A1(182-1241) [extracellular region] (Homo sapiens)