Reactome | ddl-2 [cytosol]

ddl-2 [cytosol]

Stable Identifier

R-CEL-2197670

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

WIPF3, O18195

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Innate Immune System (Caenorhabditis elegans)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
    - Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
      - Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
      - Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
  - Signaling by Rho GTPases (Caenorhabditis elegans)
    - RHO GTPase Effectors (Caenorhabditis elegans)
      - RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
        
        ddl-2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O18195

Gene Names

ddl-2

Reference Genes

BioGPS Gene:190025 ddl-2

ENSEMBL:WBGene00013000

Monarch:190025 ddl-2

NCBI Gene:190025 ddl-2

UCSC:O18195 ddl-2

Wormbase:WBGene00013000

Reference Transcript

RefSeq:NM_064446.1 ddl-2

Other Identifiers

184139_at

18505629

190025

A_12_P103307

A_12_P158900

CE14854

CE_WBGene00013000_A

CGZ0047177

GO:0005768

GO:0005769

GO:0007010

GO:0008092

GO:0031410

GO:0034314

GO:0043014

GO:0043226

GO:0071203

WBGene00013000

Y48E1B.1

Y48E1B.1_1227-1286_0.925_1_A

Y48E1B.1_1371-1430_0.885_7_B

Y48E1B.1_141-200_0.723_57_C

Y48E1B_1P00001

Y48E1B_1P00344

Y48E1B_1P00609

cea2.i.16989

Participates

as a component of

Inferred From

WIP family proteins [cytosol] (Homo sapiens)

WIPF3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_496847.1

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