Reactome | lip-1 [nucleoplasm]

lip-1 [nucleoplasm]

Stable Identifier

R-CEL-2871619

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

DUSP6, V6CIV8

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-17 signaling (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Toll-like Receptor Cascades (Caenorhabditis elegans)
    - Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
      - Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
      - Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
      - MyD88-independent TLR4 cascade (Caenorhabditis elegans)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by NTRKs (Caenorhabditis elegans)
    - Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
      - Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)
        
        lip-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:V6CIV8

Gene Names

lip-1

Reference Genes

BioGPS Gene:191704 lip-1

ENSEMBL:WBGene00003043

Monarch:191704 lip-1

NCBI Gene:191704 lip-1

UCSC:V6CIV8 lip-1

Wormbase:WBGene00003043

Reference Transcript

Other Identifiers

18533086

191704

193185_at

A_12_P117121

C05B10.1

C05B10.1_550-609_0.908_9_C

C05B10.1_831-890_0.920_4_B

C05B10.1_956-1015_0.942_1_A

C05B10_1P00053

C05B10_1P00351

C05B10_1P00821

CE31151

CE_WBGene00003043_A

CE_WBGene00003043_B

CE_WBGene00003043_C

CGZ0002460

GO:0003824

GO:0006470

GO:0008138

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0036211

GO:0140096

WBGene00003043

cea2.p.85256

Participates

as a member of

ERK-specific DUSP [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

lip-1 [cytosol]

lip-1 [nucleoplasm]

Inferred From

DUSP6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_501053.2, NP_001293707.1

IntEnz

3.1.3.16

PRO

V6CIV8

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