Reactome | chc-1 [cytosol]

chc-1 [cytosol]

Stable Identifier

R-CEL-350824

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

CLTC-1, P34574

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - clathrin:HSPA8:ADP [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)
      - Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin-coated vesicle [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
  - trans-Golgi Network Vesicle Budding (Caenorhabditis elegans)
    - Golgi Associated Vesicle Biogenesis (Caenorhabditis elegans)
      - trans-Golgi Network Coat Assembly (Caenorhabditis elegans)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
        
        Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
    - Lysosome Vesicle Biogenesis (Caenorhabditis elegans)
      - trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
        
        Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)
        
        Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Caenorhabditis elegans)
        
        Clathrin Triskelion [cytosol] (Caenorhabditis elegans)
        
        chc-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P34574

Gene Names

chc-1

Reference Genes

BioGPS Gene:176434 chc-1

CTD Gene:176434 chc-1

ENSEMBL:WBGene00011867

KEGG:cel:CELE_T20G5.1 chc-1

Monarch:176434 chc-1

NCBI Gene:176434 chc-1

UCSC:P34574 chc-1

Wormbase:WBGene00011867

Wormbase:WBGene00011867 chc-1

Reference Transcript

RefSeq:NM_066859.4 chc-1

Other Identifiers

176434

18515668

190472_s_at

A_12_P116441

CE00480

CE_WBGene00011867_A

CE_WBGene00011867_B

CGZ0035752

GO:0005198

GO:0005515

GO:0005737

GO:0005886

GO:0005905

GO:0005938

GO:0006886

GO:0006898

GO:0007010

GO:0008104

GO:0008340

GO:0009792

GO:0009898

GO:0016192

GO:0016324

GO:0030130

GO:0030132

GO:0030139

GO:0030659

GO:0030866

GO:0031410

GO:0032051

GO:0043226

GO:0045176

GO:0045334

GO:0048856

GO:0071439

GO:0072686

GO:2000370

T20G5.1

T20G5.1_4405-4464_0.904_15_C

T20G5.1_4486-4545_0.918_6_B

T20G5.1_4624-4683_0.933_3_A

T20G5_1P03908

T20G5_1P04243

T20G5_1P04899

T20G5_9P00001

WBGene00011867

cea2.p.74209

Participates

as a candidate of

as a component of

Clathrin Triskelion [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

chc-1 [cytosol]

chc-1 [trans-Golgi network membrane]

chc-1 [endolysosome membrane]

chc-1 [clathrin-coated endocytic vesicle membrane]

chc-1 [lysosomal membrane]

chc-1 [plasma membrane]

Inferred From

Clathrin heavy chain [cytosol] (Homo sapiens)

CLTC [cytosol] (Homo sapiens)

CLTC-1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

T20G5.1.1, T20G5.1.1, WBGene00011867

PRO

P34574

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