Reactome | let-418 [nucleoplasm]

let-418 [nucleoplasm]

Stable Identifier

R-CEL-3702078

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

CHD4, G5EBZ4

Locations in the PathwayBrowser

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Chromatin organization (Caenorhabditis elegans)

- Chromatin modifying enzymes (Caenorhabditis elegans)
  - HDACs deacetylate histones (Caenorhabditis elegans)
    - HDAC1/2 containing-complexes deacetylate histones (Caenorhabditis elegans)
      - HDAC1/2 deacetylase complexes [nucleoplasm] (Caenorhabditis elegans)
        
        NuRD complex [nucleoplasm] (Caenorhabditis elegans)
        
        Mi-2 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CHD4 [nucleoplasm] (Caenorhabditis elegans)
        
        let-418 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - PIP3 activates AKT signaling (Caenorhabditis elegans)
    - PTEN Regulation (Caenorhabditis elegans)
      - Regulation of PTEN gene transcription (Caenorhabditis elegans)
        
        SALL4 recruits NuRD to PTEN gene (Caenorhabditis elegans)
        
        NuRD complex [nucleoplasm] (Caenorhabditis elegans)
        
        Mi-2 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CHD4 [nucleoplasm] (Caenorhabditis elegans)
        
        let-418 [nucleoplasm] (Caenorhabditis elegans)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Caenorhabditis elegans)
        
        SALL4:NuRD [nucleoplasm] (Caenorhabditis elegans)
        
        NuRD complex [nucleoplasm] (Caenorhabditis elegans)
        
        Mi-2 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CHD4 [nucleoplasm] (Caenorhabditis elegans)
        
        let-418 [nucleoplasm] (Caenorhabditis elegans)
- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by NTRKs (Caenorhabditis elegans)
    - Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
      - Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
        
        NGF-stimulated transcription (Caenorhabditis elegans)
        
        NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)
        
        Homologues of CHD4 [nucleoplasm] (Caenorhabditis elegans)
        
        let-418 [nucleoplasm] (Caenorhabditis elegans)
        
        RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CHD4 [nucleoplasm] (Caenorhabditis elegans)
        
        let-418 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EBZ4

Gene Names

let-418

Reference Genes

BioGPS Gene:178970 let-418

CTD Gene:178970 let-418

ENSEMBL:WBGene00002637

KEGG Gene (Caenorhabditis elegans):CELE_F26F12.7 let-418

Monarch:178970 let-418

NCBI Gene:178970 let-418

Wormbase:WBGene00002637

Reference Transcript

RefSeq:NM_072122.4 let-418

Other Identifiers

178970

18568391

189004_at

A_12_P101181

A_12_P171902

AAG29838

CCD62685

CE17716

CE_WBGene00002637_A

CE_WBGene00002637_B

cea2.c.35722

CGZ0018374

EntrezGene:178970

EntrezGene:let-418

F26F12.7

F26F12.7.1

F26F12.7_4760-4819_0.882_19_C

F26F12.7_4933-4992_0.926_6_B

F26F12.7_5159-5218_0.948_2_A

F26F12_7P04017

F26F12_7P04708

F26F12_7P04967

GO:0000122

GO:0000166

GO:0000228

GO:0000977

GO:0003674

GO:0003677

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0008134

GO:0008150

GO:0009058

GO:0009790

GO:0016581

GO:0016787

GO:0016887

GO:0032991

GO:0034641

GO:0040027

GO:0043167

GO:0043226

GO:0046872

GO:0048557

GO:0048856

GO:0090571

IPR000330

IPR000953

IPR001650

IPR001965

IPR002464

IPR009462

IPR009463

IPR011011

IPR012957

IPR012958

IPR013083

IPR014001

IPR016197

IPR019786

IPR019787

IPR023780

IPR027417

IPR038718

let-418

NP_504523

PF00176

PF00271

PF00385

PF00628

PF06461

PF06465

PF08073

PF08074

SM00249

SM00298

SM00487

SM00490

SM01146

SM01147

UPI00000765C9

WBGene00002637

Participant Of

hasMember

Homologues of CHD4 [nucleoplasm]

Other forms of this molecule

let-418 [nucleoplasm]

Inferred From

CHD4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_504523.1

PRO

G5EBZ4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q21502	1	mep-1 [nucleoplasm] (R-CEL-480506-6)	0.499	2

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