Reactome | tkr-1 [plasma membrane]

tkr-1 [plasma membrane]

Stable Identifier

R-CEL-380103

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

TACR1, Q03566

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
      - ARRB bind GPCRs (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        tkr-1 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q03566

Gene Names

tkr-1

Reference Genes

BioGPS Gene:192055 tkr-1

ENSEMBL:WBGene00006576

Monarch:192055 tkr-1

NCBI Gene:192055 tkr-1

Wormbase:WBGene00006576

Reference Transcript

RefSeq:NM_066663.4 tkr-1

Other Identifiers

18509846

192055

193134_at

A_12_P110703

C38C10.1

C38C10.1_136-195_0.866_30_C

C38C10.1_374-433_0.909_10_A

C38C10.1_55-114_0.867_29_B

C38C10_1P00181

C38C10_1P00389

C38C10_1P00855

CE00104

CE_WBGene00006576_A

CE_WBGene00006576_B

CGZ0008101

GO:0004930

GO:0004995

GO:0005886

GO:0007186

GO:0016020

GO:0023052

GO:0060089

WBGene00006576

cea2.i.18976

Participates

as a candidate of

ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

tkr-1 [clathrin-coated endocytic vesicle membrane]

tkr-1 [plasma membrane]

Inferred From

TACR1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_499064.2

PRO

Q03566

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