Reactome | aakb-1 [cytosol]

aakb-1 [cytosol]

Stable Identifier

R-CEL-380968

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

PRKAB1, Q9XUY2

Locations in the PathwayBrowser

Expand all

Autophagy (Caenorhabditis elegans)

- Macroautophagy (Caenorhabditis elegans)
  - AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - ULK complex translocates to the ER (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
        
        SESN1,2,3 bind AMPK (Caenorhabditis elegans)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK beta [cytosol] (Caenorhabditis elegans)
        
        aakb-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XUY2

Gene Names

aakb-1

Reference Genes

ENSEMBL:WBGene00010115

UCSC:Q9XUY2 aakb-1

Wormbase:WBGene00010115

Reference Transcript

RefSeq:NM_077897.6 aakb-1

Other Identifiers

178382_s_at

181492

18611840

A_12_P105769

A_12_P150840

A_12_P150841

CE18744

CE_WBGene00010115_A

CE_WBGene00010115_B

CGZ0024342

F55F3.1

F55F3.1_510-569_0.944_3_C

F55F3.1_685-744_0.948_2_B

F55F3.1_760-819_0.969_1_A

F55F3_1P00052

F55F3_1P00463

F55F3_1P00722

GO:0005515

WBGene00010115

cea2.c.45761

Participates

as a member of

AMPK beta [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

aakb-1 [nucleoplasm]

aakb-1 [cytosol]

Inferred From

PRKAB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_510298.1

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