Reactome | mec-15 [cytosol]

mec-15 [cytosol]

Stable Identifier

R-CEL-391290

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

FBXW9, Q22071

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
    - Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
      - Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
      - Polyubiquitination of substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
      - Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
      - Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Neddylation (Caenorhabditis elegans)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
        
        CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        mec-15 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q22071

Gene Names

mec-15

Reference Genes

BioGPS Gene:174587 mec-15

CTD Gene:174587 mec-15

ENSEMBL:WBGene00003177

KEGG Gene (Caenorhabditis elegans):CELE_T01E8.4 mec-15

Monarch:174587 mec-15

NCBI Gene:174587 mec-15

UCSC:Q22071 mec-15

Wormbase:WBGene00003177

Reference Transcript

RefSeq:NM_063806.6 mec-15

Other Identifiers

174587

18502403

190869_s_at

A_12_P105866

A_12_P166944

A_12_P166945

A_12_P166946

CE02308

CE_WBGene00011332_A

CGZ0032664

GO:0005515

T01E8.4

T01E8.4_293-352_0.888_22_C

T01E8.4_373-432_0.863_40_B

T01E8.4_442-501_0.885_24_A

T01E8_4P00239

T01E8_4P00636

T01E8_4P01024

WBGene00011332

cea2.c.13904

Participates

as a member of

F-box protein [cytosol] (Caenorhabditis elegans)

Inferred From

FBXW9 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_496207.1

PRO

Q22071

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