Reactome | vhl-1 [cytosol]

vhl-1 [cytosol]

Stable Identifier

R-CEL-391423

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

VHL, Q19213

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
    - Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
      - Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - Polyubiquitination of substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Neddylation (Caenorhabditis elegans)
    - 26S proteasome degrades HIFalpha (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
        
        CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        CUL2-box protein [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        CUL2-box protein [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        CUL2-box protein [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        CUL2-box protein [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        vhl-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19213

Gene Names

vhl-1

Reference Genes

BioGPS Gene:181321 vhl-1

CTD Gene:181321 vhl-1

ENSEMBL:WBGene00006922

KEGG Gene (Caenorhabditis elegans):CELE_F08G12.4 vhl-1

Monarch:181321 vhl-1

NCBI Gene:181321 vhl-1

UCSC:Q19213 vhl-1

Wormbase:WBGene00006922

Reference Transcript

RefSeq:NM_077488.3 vhl-1

Other Identifiers

181321

181583_at

18607440

A_12_P101803

CE03169

CE_WBGene00006922_A

CE_WBGene00006922_B

CGZ0014950

F08G12.4

F08G12.4_199-258_0.914_3_B

F08G12.4_451-510_0.927_1_A

F08G12.4_49-108_0.901_6_C

F08G12_4P00055

F08G12_4P00197

F08G12_4P00306

WBGene00006922

cea2.p.139391

Participates

as a member of

as a component of

VBC complex [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

vhl-1 [nucleoplasm]

Inferred From

VHL [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_509889.1

PRO

Q19213

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q18953 SPCS			0.488	2

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