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pix-1 [cytosol]
Stable Identifier
R-CEL-430346
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
ARHGEF7, Q21430
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
Ephrin signaling (Caenorhabditis elegans)
GIT1 binds bPIX (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
PAK binds RAC and bPIX (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
PAKs autophosphorylate (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
PAKs phosphorylate MLC (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA GEFs activate RHOA (Caenorhabditis elegans)
RHOA GEFs [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
RHOQ GTPase cycle (Caenorhabditis elegans)
RHOQ binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOQ effectors [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Caenorhabditis elegans)
RHOQ effectors [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
RHOV GTPase cycle (Caenorhabditis elegans)
RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOV effectors [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
RHOV:GTP:RHOV effectors [plasma membrane] (Caenorhabditis elegans)
RHOV effectors [cytosol] (Caenorhabditis elegans)
pix-1 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q21430
Gene Names
pix-1
Reference Genes
BioGPS Gene:181490 pix-1
CTD Gene:181490 pix-1
ENSEMBL:WBGene00010776
KEGG:cel:CELE_K11E4.4 pix-1
Monarch:181490 pix-1
NCBI Gene:181490 pix-1
UCSC:Q21430 pix-1
Wormbase:WBGene00010776
Reference Transcript
RefSeq:NM_001270298.1 pix-1
Other Identifiers
174229_at
175332_at
181490
18613526
18613567
190219_at
A_12_P112474
CE18886
CE_WBGene00010776_A
CE_WBGene00010776_B
CGZ0029218
CGZ0029219
GO:0001764
GO:0005085
GO:0005515
GO:0005737
GO:0005912
GO:0022414
GO:0030056
GO:0035262
GO:0040039
GO:0048870
GO:0071944
GO:0098772
K11E4.4
K11E4.4_1256-1315_0.902_18_C
K11E4.4_1391-1450_0.922_8_B
K11E4.4_1713-1772_0.935_2_A
K11E4_4P01048
K11E4_4P01927
K11E4_4P02399
WBGene00010776
cea2.3.20077
cea2.p.150208
Participates
as a candidate of
RHOA GEFs [cytosol] (Caenorhabditis elegans)
RHOV effectors [cytosol] (Caenorhabditis elegans)
RHOQ effectors [cytosol] (Caenorhabditis elegans)
CDC42 effectors [cytosol] (Caenorhabditis elegans)
RHOJ effectors [cytosol] (Caenorhabditis elegans)
as an input of
GIT1 binds bPIX (Caenorhabditis elegans)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
pix-1 [cytosol]
Inferred From
ARHGEF7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001257227.1
ENSEMBL
K11E4.4a.1
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