Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-p-S218,T222-MAP2K3 [nucleoplasm]
Stable Identifier
R-CEL-450229
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
Q21307
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q21307
Reference Genes
BioGPS Gene:181004
CTD Gene:181004
ENSEMBL:WBGene00003185
Monarch:181004
NCBI Gene:181004
UCSC:Q21307
Wormbase:WBGene00003185
Reference Transcript
RefSeq:NM_001029600.4
Other Identifiers
174048_at
181004
18613103
A_12_P102516
A_12_P105703
A_12_P131090
CE_WBGene00003185_A
CE_WBGene00003185_B
CGZ0028342
GO:0003824
GO:0004672
GO:0005524
GO:0006468
GO:0016740
GO:0036211
GO:0140096
K08A8.1
K08A8.1a_222-281_0.905_3_B
K08A8.1a_467-526_0.926_1_A
K08A8.1a_950-1009_0.876_9_C
K08A8_1aP00871
K08A8_1aP00896
K08A8_1aP00979
K08A8_1bP00074
K08A8_1bP00629
K08A8_1bP00779
WBGene00003185
cea2.c.46816
Participates
as a member of
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Other forms of this molecule
MAP2K6 [cytosol]
MAP2K3 [cytosol]
phospho-p-S207,T211-MAP2K6 [cytosol]
phospho-p-S218,T222-MAP2K3 [cytosol]
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
Inferred From
p-S218,T222-MAP2K3 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001024771.1
PRO
Q21307
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text