Reactome | cit-1.2 [nucleoplasm]

cit-1.2 [nucleoplasm]

Stable Identifier

R-CEL-51611

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

CCNT1, P34424

Locations in the PathwayBrowser

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Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - TP53 Regulates Transcription of DNA Repair Genes (Caenorhabditis elegans)
        
        CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Caenorhabditis elegans)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Caenorhabditis elegans)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Caenorhabditis elegans)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Caenorhabditis elegans)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
  - RNA Polymerase II Pre-transcription Events (Caenorhabditis elegans)
    - 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)
      - Paused processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Abortive termination of elongation after arrest (Caenorhabditis elegans)
      - Aborted elongation complex after arrest [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Formation of P-TEFb complex (Caenorhabditis elegans)
      - CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Resumption of elongation after recovery from pausing (Caenorhabditis elegans)
      - Paused processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
  - RNA Polymerase II Transcription Elongation (Caenorhabditis elegans)
    - Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)
      - Elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Formation of RNA Pol II elongation complex (Caenorhabditis elegans)
      - Recruitment of elongation factors to form elongation complex (Caenorhabditis elegans)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
        
        Elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)
      - Elongation complex prior to separation [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - Processive elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Separation of elongating transcript from template (Caenorhabditis elegans)
      - Elongation complex prior to separation [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - Elongation complex with separated and uncleaved transcript [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
  - RNA polymerase II transcribes snRNA genes (Caenorhabditis elegans)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Caenorhabditis elegans)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Nuclear Receptors (Caenorhabditis elegans)
  - ESR-mediated signaling (Caenorhabditis elegans)
    - Estrogen-dependent gene expression (Caenorhabditis elegans)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)
- Signaling by TGFB family members (Caenorhabditis elegans)
  - Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Caenorhabditis elegans)
        
        P-TEFb complex [nucleoplasm] (Caenorhabditis elegans)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)
        
        cit-1.2 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P34424

Gene Names

cit-1.2

Reference Genes

BioGPS Gene:176126 cit-1.2

CTD Gene:176126 cit-1.2

ENSEMBL:WBGene00000508

Monarch:176126 cit-1.2

NCBI Gene:176126 cit-1.2

UCSC:P34424 cit-1.2

Wormbase:WBGene00000508

Reference Transcript

Other Identifiers

175479_at

176126

176657_at

18512067

A_12_P116573

A_12_P162848

A_12_P162849

CE32417

CE_WBGene00000508_A

CE_WBGene00000508_B

CE_WBGene00000508_C

CGZ0011410

CGZ0021553

F44B9.3

F44B9.3a

F44B9.3a_1005-1064_0.913_13_A

F44B9.3a_657-716_0.887_32_C

F44B9.3a_776-835_0.890_27_B

F44B9.3b

F44B9_3aP00198

F44B9_3aP00253

F44B9_3aP00410

F44B9_3bP00101

F44B9_3bP00640

F44B9_3bP00898

GO:0006351

GO:0006355

GO:0006357

GO:0016538

GO:0098772

WBGene00000508

cea2.d.25681

cea2.p.64429

Participates

as a member of

Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)

Inferred From

CCNT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_871655.1, NP_498745.1

PRO

P34424

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9N2Z7	3	wwp-1 [cytosol] (R-CEL-975995) wwp-1 [cytosol] (R-CEL-976037) wwp-1 [cytosol] (R-CEL-6807279)	0.488	2

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