Reactome | snt-5 [plasma membrane]

snt-5 [plasma membrane]

Stable Identifier

R-CEL-5216119-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

SYT8, O16700

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - STON2 binds SYT proteins (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        STON2,1:SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT dimers [plasma membrane] (Caenorhabditis elegans)
        
        SYT8 dimer [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)
        
        snt-5 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O16700

Gene Names

snt-5

Reference Genes

BioGPS Gene:178631 snt-5

CTD Gene:178631 snt-5

ENSEMBL:WBGene00004925

Monarch:178631 snt-5

NCBI Gene:178631 snt-5

UCSC:O16700 snt-5

Wormbase:WBGene00004925

Reference Transcript

RefSeq:NM_071008.3 snt-5

Other Identifiers

178631

182682_at

18594494

A_12_P115615

A_12_P155540

A_12_P155541

CE29448

CE_WBGene00004925_A

CGZ0032000

GO:0016020

R12A1.2

R12A1.2_1121-1180_0.924_8_C

R12A1.2_1229-1288_0.956_1_A

R12A1.2_1323-1382_0.925_7_B

R12A1_2P00143

R12A1_2P00328

R12A1_2P00958

WBGene00004925

cea2.p.122548

Participates

as a member of

Homologues of SYT8 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

snt-5 [clathrin-coated endocytic vesicle membrane]

snt-5 [plasma membrane]

Inferred From

SYT8 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_503409.1

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