Reactome | GNA12 [plasma membrane]

GNA12 [plasma membrane]

Stable Identifier

R-CEL-55355

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

Q19572

Locations in the PathwayBrowser

Expand all

Hemostasis (Caenorhabditis elegans)

- Platelet activation, signaling and aggregation (Caenorhabditis elegans)
  - Thrombin signalling through proteinase activated receptors (PARs) (Caenorhabditis elegans)
    - Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (active) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
    - Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)
      - G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (active) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR downstream signalling (Caenorhabditis elegans)
    - G alpha (12/13) signalling events (Caenorhabditis elegans)
      - G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GDP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - Inactive G alpha (12/13) reassociates with G beta:gamma (Caenorhabditis elegans)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GDP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - LARG activation by G alpha 12/13 (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):LARG [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - LARG binds plexin B1 (Caenorhabditis elegans)
        
        G-protein alpha (12/13):LARG [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):LARG:Plexin B1 [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):LARG [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (active) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GDP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
      - The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)
        
        G-protein alpha (12/13):GTP [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Caenorhabditis elegans)
        
        G-protein G12/G13 (active) [plasma membrane] (Caenorhabditis elegans)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Caenorhabditis elegans)
        
        G-protein alpha (12):GTP [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)
        
        GNA12 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19572

Reference Genes

BioGPS Gene:181157

ENSEMBL:WBGene00001674

KEGG Gene (Caenorhabditis elegans):CELE_F18G5.3

Monarch:181157

NCBI Gene:181157

UCSC:Q19572

Wormbase:WBGene00001674

Reference Transcript

RefSeq:NM_077156.3

Other Identifiers

181157

18608640

193594_at

A_12_P102204

CE20692

CE_WBGene00001674_A

CE_WBGene00001674_B

CGZ0016936

F18G5.3

F18G5.3_468-527_0.912_4_C

F18G5.3_846-905_0.941_1_A

F18G5.3_996-1055_0.924_3_B

F18G5_3P00174

F18G5_3P00567

F18G5_3P00844

GO:0001664

GO:0003824

GO:0003924

GO:0007165

GO:0007186

GO:0007266

GO:0016787

GO:0019001

GO:0023052

GO:0031683

WBGene00001674

cea2.c.44090

Participates

as a member of

Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

GNA13 [plasma membrane]

Inferred From

GNA12 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_509557.1

PRO

Q19572

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