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phospho-lin-45 [plasma membrane]
Stable Identifier
R-CEL-5672665
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
plasma membrane
Synonyms
p-S338,Y341,T491,S494,S621 RAF1, Q07292
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Caenorhabditis elegans)
activated RAF/KSR1 [plasma membrane] (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
Negative feedback regulation of MAPK pathway (Caenorhabditis elegans)
Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)
phospho-lin-45 [plasma membrane] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q07292
Gene Names
lin-45
Reference Genes
BioGPS Gene:177436 lin-45
CTD Gene:177436 lin-45
ENSEMBL:WBGene00003030
Monarch:177436 lin-45
NCBI Gene:177436 lin-45
UCSC:Q07292 lin-45
Wormbase:WBGene00003030
Reference Transcript
RefSeq:NM_171367.5 lin-45
Other Identifiers
173413_at
177436
18560058
191672_s_at
A_12_P106218
A_12_P107130
A_12_P179449
A_12_P179450
A_12_P179451
A_12_P179452
A_12_P179453
CE25585
CE_WBGene00003030_A
CGZ0053119
CGZ0053121
GO:0000003
GO:0000165
GO:0000166
GO:0001708
GO:0002119
GO:0003674
GO:0004672
GO:0004674
GO:0005524
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007165
GO:0007265
GO:0007275
GO:0008150
GO:0016301
GO:0016310
GO:0016740
GO:0017016
GO:0019899
GO:0030154
GO:0035556
GO:0040025
GO:0043167
GO:0046872
GO:0048477
GO:0048856
GO:0050830
GO:0051321
WBGene00003030
Y73B6A.5
Y73B6A.5a
Y73B6A.5a_1408-1467_0.874_61_C
Y73B6A.5a_1510-1569_0.890_48_B
Y73B6A.5a_1645-1704_0.900_40_A
Y73B6A.5b
Y73B6A_4P00368
Y73B6A_5aP01698
Y73B6A_5aP02008
Y73B6A_5aP02298
Y73B6A_5bP00537
Y73B6A_5bP01014
Y73B6A_5bP01309
cea2.3.30311
cea2.c.32496
cea2.d.07330
Participant Of
input
Activated MAPK phosphorylates RAF1
hasMember
activated RAF/KSR1 [plasma membrane]
Other forms of this molecule
lin-45 [cytosol]
phospho-lin-45 [cytosol]
phospho-lin-45 [cytosol]
phospho-lin-45 [plasma membrane]
phospho-lin-45 [cytosol]
phospho-lin-45 [cytosol]
phospho-lin-45 [plasma membrane]
phospho-lin-45 [cytosol]
phospho-lin-45 [cytosol]
Inferred From
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_741430.3
PRO
Q07292
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