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xpa-1 [nucleoplasm]
Stable Identifier
R-CEL-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
XPA, Q21302
Locations in the PathwayBrowser
Expand all
DNA Repair (Caenorhabditis elegans)
Nucleotide Excision Repair (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Dual Incision in GG-NER (Caenorhabditis elegans)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Caenorhabditis elegans)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Caenorhabditis elegans)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Formation of Incision Complex in GG-NER (Caenorhabditis elegans)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
SUMOylation of XPC (Caenorhabditis elegans)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
Dual incision in TC-NER (Caenorhabditis elegans)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)
TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)
TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Formation of TC-NER Pre-Incision Complex (Caenorhabditis elegans)
Assembly of the pre-incision complex in TC-NER (Caenorhabditis elegans)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Caenorhabditis elegans)
xpa-1 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q21302
Gene Names
xpa-1
Reference Genes
BioGPS Gene:187120 xpa-1
CTD Gene:187120 xpa-1
ENSEMBL:WBGene00006963
Monarch:187120 xpa-1
NCBI Gene:187120 xpa-1
Wormbase:WBGene00006963
Reference Transcript
RefSeq:NM_059624.1 xpa-1
Other Identifiers
18457996
187120
192720_at
A_12_P105036
CE06130
CE_WBGene00006963_A
CE_WBGene00006963_B
CE_WBGene00006963_C
CGZ0028289
GO:0003677
GO:0003684
GO:0006281
GO:0006289
K07G5.2
K07G5.2_247-306_0.937_6_C
K07G5.2_471-530_0.948_3_B
K07G5.2_633-692_0.957_1_A
K07G5_2P00219
K07G5_2P00347
K07G5_2P00442
WBGene00006963
cea2.i.03658
Participates
as a component of
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Caenorhabditis elegans)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Caenorhabditis elegans)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
as an input of
Assembly of the pre-incision complex in TC-NER (Caenorhabditis elegans)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_492025.1
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