Reactome | WWP2 [cytosol]

WWP2 [cytosol]

Stable Identifier

R-CEL-6807279

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q9N2Z7

Locations in the PathwayBrowser

Expand all

Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - PIP3 activates AKT signaling (Caenorhabditis elegans)
    - PTEN Regulation (Caenorhabditis elegans)
      - Regulation of PTEN stability and activity (Caenorhabditis elegans)
        
        NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)
        
        NEDD4,STUB1,WWP2 and XIAP [cytosol] (Caenorhabditis elegans)
        
        WWP2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9N2Z7

Reference Genes

BioGPS Gene:171647

CTD Gene:171647

dbSNP Gene:171647

ENSEMBL:WBGene00007009

KEGG Gene (Caenorhabditis elegans):CELE_Y65B4BR.4

Monarch:171647

NCBI Gene:171647

UCSC:Q9N2Z7

Wormbase:WBGene00007009

Reference Transcript

RefSeq:NM_170794.6

Other Identifiers

171647

175034_at

18462908

187163_at

A_12_P105060

A_12_P142350

CCD71931

CE31384

CE_WBGene00007009_A

CE_WBGene00007009_B

CE_WBGene00007009_C

cea2.d.46210

CGZ0052001

EntrezGene:171647

EntrezGene:wwp-1

GO:0000209

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0006464

GO:0006511

GO:0007568

GO:0008150

GO:0008340

GO:0009056

GO:0016567

GO:0016740

GO:0016874

GO:0042176

GO:0043161

GO:0045732

GO:0048856

GO:0061630

GO:0061631

IPR000008

IPR000569

IPR001202

IPR024928

IPR035892

IPR035983

IPR036020

NP_740775

PF00168

PF00397

PF00632

SM00119

SM00239

SM00456

UPI0000083942

WBGene00007009

wwp-1

Y65B4BR.4

Y65B4BR.4a

Y65B4BR.4a.1

Y65B4BR.4a_1758-1817_0.906_3_B

Y65B4BR.4a_1904-1963_0.926_1_A

Y65B4BR.4a_2062-2121_0.908_2_C

Y65B4BR_4aP00933

Y65B4BR_4aP01594

Y65B4BR_4aP02227

Participant Of

hasMember

NEDD4,STUB1,WWP2 and XIAP [cytosol]

Other forms of this molecule

ITCH [cytosol]

WWP1 [cytosol]

HACE1 [cytosol]

Inferred From

WWP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_740775.1

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q21633	6	UBE2L3 [nucleoplasm] (R-CEL-8852056) Ub-C86-UBE2L3 [nucleoplasm] (R-CEL-8864226) Ub-C86-UBE2L3 [cytosol] (R-CEL-8864201) UBE2L6 [nucleoplasm] (R-CEL-5653666) UBE2L3 [cytosol] (R-CEL-947631) UBE2L6 [cytosol] (R-CEL-936014)	0.635	3
UniProt:Q18966 Q18966			0.621	3
UniProt:Q9XXI4	1	TXNIP [cytosol] (R-CEL-1250246-25)	0.621	3
UniProt:Q9XVA4 YS0I			0.488	2
UniProt:O62203	2	SAFB [nucleoplasm] (R-CEL-4085379) SUMO1-K231,K294-SAFB [nucleoplasm] (R-CEL-4085343)	0.488	2
UniProt:Q9U252 Q9U252			0.488	2
UniProt:Q17865 YTE4			0.488	2
UniProt:G5EG65 G5EG65			0.488	2
UniProt:Q9XWV4 Q9XWV4			0.488	2
UniProt:Q86NH1	2	SYDE2 [cytosol] (R-CEL-200589) SYDE1 [cytosol] (R-CEL-2980861)	0.488	2
UniProt:H2KZI6	1	ZC3H8 [nucleoplasm] (R-CEL-6807406)	0.488	2
UniProt:Q9TZL2 Q9TZL2			0.488	2
UniProt:Q9U2N7 Q9U2N7			0.488	2
UniProt:P34424 CCNT2			0.488	2
UniProt:Q95PX7 Q95PX7			0.488	2
UniProt:Q22805	1	ZC3H8 [nucleoplasm] (R-CEL-6807406-2)	0.488	2
UniProt:Q19016 Q19016			0.488	2
UniProt:Q23536	6	MAP1LC3B(2-121) [cytosol] (R-CEL-5682674) MAP1LC3A(1-121) [cytosol] (R-CEL-5682681) MAP1LC3B [autophagosome membrane] (R-CEL-5683641) MAP1LC3A [autophagosome membrane] (R-CEL-5683640) MAP1LC3B [cytosol] (R-CEL-5205651) MAP1LC3A [cytosol] (R-CEL-5205676)	0.488	2
UniProt:Q19019	7	CBLB [cytosol] (R-CEL-976009) phospho-p-Y-CBL [cytosol] (R-CEL-8875457) phospho-p-Y371-CBL [plasma membrane] (R-CEL-182923) phospho-p-Y371-CBL [cytosol] (R-CEL-182940) CBL [cytosol] (R-CEL-112199) phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-CEL-8848826) phospho-p-Y700,Y731,Y774-CBL [cytosol] (R-CEL-912656)	0.488	2
UniProt:O44760 O44760			0.488	2
UniProt:P91245	2	BRI3 [azurophil granule membrane] (R-CEL-6799127) BRI3 [plasma membrane] (R-CEL-6806260)	0.488	2
UniProt:G5ED33 G5ED33			0.488	2
UniProt:P39055	12	DNM2 [lysosomal membrane] (R-CEL-2980840) DNM2 [Golgi membrane] (R-CEL-2980842) DNM1 [lysosomal membrane] (R-CEL-196150) DNM2 [cytosol] (R-CEL-2213180) DNM1 [cytosol] (R-CEL-2213182) DNM3 [cytosol] (R-CEL-2213188) MX1 [cytosol] (R-CEL-947489) MX2 [cytosol] (R-CEL-1015675) DNM2 [endocytic vesicle membrane] (R-CEL-2029000) DNM3 [plasma membrane] (R-CEL-443610) DNM2 [plasma membrane] (R-CEL-2984201) DNM1 [plasma membrane] (R-CEL-177488)	0.488	2
UniProt:Q9U304 Q9U304			0.488	2
UniProt:Q20631 Q20631			0.488	2
UniProt:Q3Y407 Q3Y407			0.488	2
UniProt:Q94184 Q94184			0.488	2
UniProt:O01900 O01900			0.488	2
UniProt:Q9U3E2 Q9U3E2			0.488	2
UniProt:Q21746	1	SGTA [cytosol] (R-CEL-5423595)	0.488	2
UniProt:Q9TZK8 Q9TZK8			0.488	2