Reactome | rfc-2 [nucleoplasm]

rfc-2 [nucleoplasm]

Stable Identifier

R-CEL-68433

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

RFC2, O44175

Locations in the PathwayBrowser

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DNA Repair (Caenorhabditis elegans)

- DNA Damage Bypass (Caenorhabditis elegans)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
    - Translesion Synthesis by POLH (Caenorhabditis elegans)
      - SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
      - SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
        
        NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
- Nucleotide Excision Repair (Caenorhabditis elegans)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
    - Dual Incision in GG-NER (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
    - Dual incision in TC-NER (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RFC Heteropentamer [nucleoplasm] (Caenorhabditis elegans)
        
        rfc-2 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O44175

Gene Names

rfc-2

Reference Genes

BioGPS Gene:176946 rfc-2

ENSEMBL:WBGene00004338

KEGG Gene (Caenorhabditis elegans):CELE_F58F6.4 rfc-2

Monarch:176946 rfc-2

NCBI Gene:176946 rfc-2

UCSC:O44175 rfc-2

Wormbase:WBGene00004338

Reference Transcript

RefSeq:NM_067668.4 rfc-2

Other Identifiers

176946

18539397

192416_at

A_12_P119945

CE17139

CE_WBGene00004338_A

CE_WBGene00004338_B

CGZ0025283

F58F6.4

F58F6.4_507-566_0.912_4_C

F58F6.4_657-716_0.938_1_A

F58F6.4_839-898_0.908_6_B

F58F6_4P00351

F58F6_4P00570

F58F6_4P00876

GO:0000166

GO:0003674

GO:0003677

GO:0003689

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005663

GO:0005694

GO:0006259

GO:0006260

GO:0006261

GO:0006281

GO:0006950

GO:0008150

GO:0009058

GO:0016887

GO:0032991

GO:0034641

GO:0043167

GO:0043226

WBGene00004338

cea2.p.94484

Participant Of

hasComponent

Inferred From

RFC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_500069.1

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