Reactome | pole-1 [nucleoplasm]

pole-1 [nucleoplasm]

Stable Identifier

R-CEL-68473

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

POLE, O62218

Locations in the PathwayBrowser

Expand all

DNA Repair (Caenorhabditis elegans)

- Base Excision Repair (Caenorhabditis elegans)
  - Resolution of Abasic Sites (AP sites) (Caenorhabditis elegans)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Caenorhabditis elegans)
      - PCNA-Dependent Long Patch Base Excision Repair (Caenorhabditis elegans)
        
        LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
- DNA Damage Bypass (Caenorhabditis elegans)
  - Recognition of DNA damage by PCNA-containing replication complex (Caenorhabditis elegans)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)
      - POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
    - Termination of translesion DNA synthesis (Caenorhabditis elegans)
      - POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
- Nucleotide Excision Repair (Caenorhabditis elegans)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
    - Dual Incision in GG-NER (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE,POLK [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
    - Dual incision in TC-NER (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
        
        POLD,POLE,POLK [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)
        
        pole-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O62218

Gene Names

pole-1

Reference Genes

BioGPS Gene:173368 pole-1

ENSEMBL:WBGene00009368

Monarch:173368 pole-1

NCBI Gene:173368 pole-1

UCSC:O62218 pole-1

Wormbase:WBGene00009368

Reference Transcript

RefSeq:NM_061215.3 pole-1

Other Identifiers

173368

18469164

192588_s_at

A_12_P102548

CE17767

CE_WBGene00009368_A

CE_WBGene00009368_C

CGZ0019525

F33H2.5

F33H2.5_5193-5252_0.869_22_C

F33H2.5_5390-5449_0.870_21_B

F33H2.5_5481-5540_0.895_10_A

F33H2_5P05028

F33H2_5P05792

F33H2_5P06318

GO:0000166

GO:0000228

GO:0003676

GO:0003677

GO:0003824

GO:0003887

GO:0005634

GO:0005694

GO:0006260

GO:0006281

GO:0008270

GO:0008622

GO:0016740

GO:0043226

GO:0140097

WBGene00009368

cea2.p.09728

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Caenorhabditis elegans)

Inferred From

POLE [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_493616.1

Cite Us!