Reactome | rla-1 [cytosol]

rla-1 [cytosol]

Stable Identifier

R-CEL-72398

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

RPLP1, P91913

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rla-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P91913

Gene Names

rla-1

Reference Genes

ENSEMBL:WBGene00004409

UCSC:P91913 rla-1

Wormbase:WBGene00004409

Reference Transcript

RefSeq:NM_170818.4 rla-1

Other Identifiers

171766

173255_at

18475408

A_12_P103290

CE26658

CE_WBGene00004409_A

CGZ0044442

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0006414

GO:0043226

WBGene00004409

Y37E3.7

Y37E3.7_10-69_0.607_13_B

Y37E3.7_238-297_0.615_12_A

Y37E3.7_77-136_0.540_16_C

Y37E3_7P00001

Y37E3_7P00073

Y37E3_7P00092

cea2.c.07218

Participates

as a component of

Inferred From

RPLP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_740801.1

PRO

P91913

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