Reactome | EIF4A2 [cytosol]

EIF4A2 [cytosol]

Stable Identifier

R-CEL-72575

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

P27639

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Interferon Signaling (Caenorhabditis elegans)
    - Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
      - ISG15 antiviral mechanism (Caenorhabditis elegans)
        
        Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)
        
        EIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        eIF4F:mRNA [cytosol] (Caenorhabditis elegans)
        
        EIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Translation (Caenorhabditis elegans)
  - Eukaryotic Translation Initiation (Caenorhabditis elegans)
    - Cap-dependent Translation Initiation (Caenorhabditis elegans)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Caenorhabditis elegans)
        
        Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Translation initiation complex formation (Caenorhabditis elegans)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
      - Ribosomal scanning and start codon recognition (Caenorhabditis elegans)
        
        Ribosomal scanning (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Start codon recognition (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Caenorhabditis elegans)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P27639

Reference Genes

BioGPS Gene:175966

CTD Gene:175966

ENSEMBL:WBGene00002083

Monarch:175966

NCBI Gene:175966

UCSC:P27639

Wormbase:WBGene00002083

Reference Transcript

Other Identifiers

175966

18512875

188535_s_at

192240_s_at

A_12_P113572

CE01341

CE_WBGene00002083_A

CE_WBGene00002083_B

CE_WBGene00002083_C

CGZ0024925

CGZ0024934

F57B9.6

F57B9.6a_1160-1219_0.932_1_A

F57B9.6a_648-707_0.917_8_C

F57B9.6a_824-883_0.922_4_B

F57B9_6aP00020

F57B9_6aP00266

F57B9_6aP00805

F57B9_6bP00017

F57B9_6bP00040

F57B9_6bP00102

GO:0003676

GO:0003724

GO:0003824

GO:0005524

GO:0140098

GO:0140657

WBGene00002083

Participates

as a member of

Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

EIF4A1 [cytosol]

Inferred From

EIF4A2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001022623.1, NP_001022624.1

PRO

P27639

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