Reactome | ifg-1 [cytosol]

ifg-1 [cytosol]

Stable Identifier

R-CEL-72584

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

EIF4G1, A0A486WX07

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        ifg-1 [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        ifg-1 [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        ifg-1 [cytosol] (Caenorhabditis elegans)
      - mRNA Cleaved by SMG6 [cytosol] (Caenorhabditis elegans)
        
        ifg-1 [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        ifg-1 [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        ifg-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:A0A486WX07

Gene Names

ifg-1

Reference Genes

BioGPS Gene:174322 ifg-1

CTD Gene:174322 ifg-1

ENSEMBL:WBGene00002066

Monarch:174322 ifg-1

NCBI Gene:174322 ifg-1

UCSC:A0A486WX07 ifg-1

Wormbase:WBGene00002066

Wormbase:WBGene00002066 ifg-1

Reference Transcript

RefSeq:NM_001381521.1 ifg-1

Other Identifiers

174322

GO:0003723

GO:0003729

GO:0003743

GO:0005515

GO:0005829

GO:0006413

GO:0016281

Participates

as a component of

as an input of

Other forms of this molecule

phospho-ifg-1 [cytosol]

ifg-1 [cytosol]

Inferred From

EIF4G1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001368728.1

ENSEMBL

WBGene00002066, M110.4e.1, M110.4e.1