Reactome | sem-5 [cytosol]

sem-5 [cytosol]

Stable Identifier

R-CEL-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

GRB2-1, P29355

Locations in the PathwayBrowser for interactor UniProt:Q62245

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Hemostasis (Caenorhabditis elegans)

- Platelet activation, signaling and aggregation (Caenorhabditis elegans)
  - Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
    - Integrin signaling (Caenorhabditis elegans)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
        
        Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
        
        sem-5 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P29355

Gene Names

sem-5

Reference Genes

BioGPS Gene:181055 sem-5

CTD Gene:181055 sem-5

ENSEMBL:WBGene00004774

Monarch:181055 sem-5

NCBI Gene:181055 sem-5

UCSC:P29355 sem-5

Wormbase:WBGene00004774

Reference Transcript

RefSeq:NM_076941.5 sem-5

Other Identifiers

181055

18619882

187892_at

A_12_P118939

C14F5.5

C14F5.5_437-496_0.941_8_C

C14F5.5_496-555_0.941_6_B

C14F5.5_620-679_0.964_1_A

C14F5_5P00008

C14F5_5P00418

C14F5_5P00581

CE01784

CE_WBGene00004774_A

CGZ0004660

GO:0005515

WBGene00004774

cea2.c.41317

Participates

as a component of

as a member of

as an input of

Inferred From

GRB2-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_509342.1

PRO

P29355

PDB

1KFZ, 2SEM, 3SEM, 1K76, 1SEM

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-7139453 PP-G4-L			0.558	2
UniProt:Q62245 Sos1	4	phospho-Sos1 [cytosol] (R-MMU-109821) Sos1 [cytosol] (R-MMU-443318) Sos1 [plasma membrane] (R-MMU-983559) Sos1 [cytosol] (R-MMU-64847)	0.558	2
IntAct:EBI-7139534 L			0.558	2
UniProt:Q9TYS3	8	ftn-2 [extracellular region] (R-CEL-2187214-2) ftn-2 [azurophil granule lumen] (R-CEL-6799149-2) ftn-2 [tertiary granule lumen] (R-CEL-6801508-2) ftn-2 [extracellular region] (R-CEL-2187212-2) ftn-2 [ficolin-1-rich granule lumen] (R-CEL-6801531-2) ftn-2 [cytosol] (R-CEL-434212-2) ftn-2 [cytosol] (R-CEL-434215-2) ftn-2 [mitochondrial matrix] (R-CEL-5691095-2)	0.553	2
UniProt:Q9N5D3	2	sos-1 [cytosol] (R-CEL-167221) sos-1 [cytosol] (R-CEL-64847)	0.553	2

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