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phospho-let-23 [plasma membrane]
Stable Identifier
R-CEL-8864079
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
plasma membrane
Synonyms
p-7Y,Y1112-ERBB2, P24348
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
RAS GEFs [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:MATK [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
ERBB2 Activates PTK6 Signaling (Caenorhabditis elegans)
Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
ERBB2 Regulates Cell Motility (Caenorhabditis elegans)
MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
SHC1 events in ERBB2 signaling (Caenorhabditis elegans)
SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Caenorhabditis elegans)
phospho-let-23 [plasma membrane] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P24348
Gene Names
let-23
Reference Genes
BioGPS Gene:174462 let-23
CTD Gene:174462 let-23
ENSEMBL:WBGene00002299
Monarch:174462 let-23
NCBI Gene:174462 let-23
UCSC:P24348 let-23
Wormbase:WBGene00002299
Reference Transcript
RefSeq:NM_063561.4 let-23
Other Identifiers
174462
18491731
194046_s_at
A_12_P100283
CE25678
CE_WBGene00002299_A
CE_WBGene00002299_B
CGZ0056193
CGZ0056194
GO:0000003
GO:0000166
GO:0002119
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005006
GO:0005524
GO:0005575
GO:0005886
GO:0005887
GO:0005911
GO:0006355
GO:0006464
GO:0006468
GO:0007165
GO:0007169
GO:0007173
GO:0007275
GO:0007568
GO:0008150
GO:0008283
GO:0008284
GO:0008340
GO:0009056
GO:0009058
GO:0009925
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016328
GO:0016740
GO:0018108
GO:0030154
GO:0030431
GO:0030539
GO:0030728
GO:0032436
GO:0032991
GO:0033674
GO:0034641
GO:0040026
GO:0043167
GO:0043235
GO:0048856
GO:0072327
WBGene00002299
ZK1067.1
ZK1067.1c_3206-3265_0.898_13_C
ZK1067.1c_3274-3333_0.910_8_A
ZK1067.1c_3356-3415_0.901_10_B
ZK1067_1P02561
ZK1067_1P03299
ZK1067_1P03634
cea2.p.53844
Participant Of
hasComponent
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane]
Other forms of this molecule
phospho-let-23 [clathrin-coated endocytic vesicle membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [mitochondrial matrix]
phospho-let-23 [mitochondrial matrix]
phospho-let-23 [nucleoplasm]
phospho-let-23 [nucleoplasm]
phospho-let-23 [cytosol]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
let-23 [plasma membrane]
let-23 [plasma membrane]
let-23 [plasma membrane]
let-23 [plasma membrane]
let-23 [plasma membrane]
let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [plasma membrane]
phospho-let-23 [cytosol]
Inferred From
p-7Y,Y1112-ERBB2 [plasma membrane] (Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1023 (in Homo sapiens)
Coordinate
1023
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1112 (in Homo sapiens)
Coordinate
1112
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1139 (in Homo sapiens)
Coordinate
1139
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1196 (in Homo sapiens)
Coordinate
1196
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1221 (in Homo sapiens)
Coordinate
1221
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1222 (in Homo sapiens)
Coordinate
1222
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1248 (in Homo sapiens)
Coordinate
1248
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 877 (in Homo sapiens)
Coordinate
877
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_495962.2
IntEnz
2.7.10.1
PRO
P24348
PDB
5WNO
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P90976 P90976
0.646
3
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