Reactome | PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CEL-8869104

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Q19625

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19625

Reference Genes

BioGPS Gene:180691

CTD Gene:180691

ENSEMBL:WBGene00003412

KEGG Gene (Caenorhabditis elegans):CELE_F20B6.3

Monarch:180691

NCBI Gene:180691

UCSC:Q19625

Wormbase:WBGene00003412

Reference Transcript

RefSeq:NM_076309.4

Other Identifiers

175209_at

180691

18624235

189342_at

A_12_P102675

A_12_P172667

A_12_P172668

A_12_P172857

A_12_P172858

A_12_P172859

A_12_P172860

A_12_P172861

CCD69756

CE04425

CE47097

CE_WBGene00003412_A

cea2.p.141606

CGZ0011266

CGZ0017113

EntrezGene:180691

EntrezGene:mrp-6

F20B6.3

F20B6.3.1

F20B6.3_3641-3700_0.915_3_C

F20B6.3_3800-3859_0.934_1_A

F20B6.3_3993-4052_0.927_2_B

F20B6_3P02826

F20B6_3P02966

F20B6_3P03544

GO:0000166

GO:0003674

GO:0005524

GO:0005575

GO:0006810

GO:0008150

GO:0008559

GO:0016020

GO:0016021

GO:0016887

GO:0022857

GO:0042626

GO:0042908

GO:0043167

GO:0055085

IPR003439

IPR003593

IPR011527

IPR017871

IPR027417

IPR030244

IPR036640

mrp-6

NP_508710

PF00005

PF00664

SM00382

UPI0002530C6C

WBGene00003412

Participant Of

hasMember

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

PolyUb-CFTR [plasma membrane]

CFTR [lysosomal membrane]

CFTR [Golgi-associated vesicle membrane]

ABCC4 [platelet dense granule membrane]

ABCC4 [plasma membrane]

CFTR [plasma membrane]

misfolded CFTR [endoplasmic reticulum membrane]

Inferred From

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_508710.3