Reactome | mrp-5 [clathrin-coated endocytic vesicle membrane]

mrp-5 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CEL-8869104

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

PolyUb-CFTR, G5EE72

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        mrp-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EE72

Gene Names

mrp-5

Reference Genes

BioGPS Gene:181587 mrp-5

CTD Gene:181587 mrp-5

ENSEMBL:WBGene00003411

KEGG Gene (Caenorhabditis elegans):CELE_F14F4.3 mrp-5

Monarch:181587 mrp-5

NCBI Gene:181587 mrp-5

Wormbase:WBGene00003411

Reference Transcript

RefSeq:NM_078078.1 mrp-5

Other Identifiers

174713_at

181587

18623755

189403_s_at

A_12_P111882

CE23650

CE_WBGene00003411_A

CGZ0016319

F14F4.3

F14F4.3a

F14F4.3b_3030-3089_0.843_61_C

F14F4.3b_3211-3270_0.860_48_B

F14F4.3b_3365-3424_0.882_33_A

F14F4_3aP02812

F14F4_3aP02975

F14F4_3aP03208

GO:0000166

GO:0003674

GO:0005524

GO:0005575

GO:0005886

GO:0006810

GO:0008150

GO:0016020

GO:0016021

GO:0016323

GO:0016887

GO:0022857

GO:0042626

GO:0043167

GO:0055085

WBGene00003411

cea2.p.140745

Participant Of

hasMember

Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

mrp-5 [plasma membrane]

mrp-5 [lysosomal membrane]

mrp-5 [Golgi-associated vesicle membrane]

mrp-5 [plasma membrane]

mrp-5 [endoplasmic reticulum membrane]

Inferred From

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_510479.1

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