Reactome | phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]

phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]

Stable Identifier

R-CEL-8875181

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

H2KZU7

Locations in the PathwayBrowser

Expand all

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by MET (Caenorhabditis elegans)
    - Negative regulation of MET activity (Caenorhabditis elegans)
      - CBL monoubiquitinates activated MET (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
      - EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:H2KZU7

Reference Genes

BioGPS Gene:180929

CTD Gene:180929

ENSEMBL:WBGene00020504

KEGG:cel:CELE_T14E8.1

Monarch:180929

NCBI Gene:180929

UCSC:H2KZU7

Wormbase:WBGene00020504

Reference Transcript

Other Identifiers

180929

18615716

190641_s_at

A_12_P106301

A_12_P155595

A_12_P155596

CE28667

CE_WBGene00020504_A

CE_WBGene00020504_B

CGZ0035149

CGZ0035150

CGZ0035151

CGZ0035152

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0016740

GO:0018108

GO:0031103

GO:0031435

GO:0038083

GO:0043235

GO:0043410

GO:0048680

GO:0048856

GO:0060089

GO:0140096

T14E8.1

T14E8.1a_2261-2320_0.881_39_C

T14E8.1a_2645-2704_0.882_38_B

T14E8.1a_2709-2768_0.916_19_A

T14E8.1b

T14E8_1aP02093

T14E8_1aP03098

T14E8_1aP03196

T14E8_1bP01982

T14E8_1bP02091

T14E8_1bP02773

WBGene00020504

cea2.d.38882

cea2.d.38922

Participates

as a member of

Homologues of MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane]

MST1R (25-304) [plasma membrane]

MST1R (310-1400) [plasma membrane]

MERTK [plasma membrane]

phospho-p-Y1349,Y1356-MET [plasma membrane]

phospho-p-Y1234,Y1235,Y1356-MET [plasma membrane]

phospho-p-Y1003,4Y-MET [plasma membrane]

phospho-MonoUb-K,p-Y1003,4Y-MET [plasma membrane]

AXL [plasma membrane]

phospho-p-Y779,Y821-AXL [plasma membrane]

MET [plasma membrane]

phospho-p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]

Inferred From

MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1234 (in Homo sapiens)

Coordinate

1234

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1235 (in Homo sapiens)

Coordinate

1235

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1349 (in Homo sapiens)

Coordinate

1349

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1356 (in Homo sapiens)

Coordinate

1356

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

ubiquitinylated lysine (Ub [cytosol]) at unknown position

Modification

Ub [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001024906.1, NP_509104.1, NP_509105.1

ENSEMBL

WBGene00020504, T14E8.1a.1, T14E8.1a.1

PRO

H2KZU7

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